Michelle Giehl
Overview
Explore the profile of Michelle Giehl including associated specialties, affiliations and a list of published articles.
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10
Citations
208
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Recent Articles
1.
Erben P, Schwaab J, Metzgeroth G, Horny H, Jawhar M, Sotlar K, et al.
Ann Hematol
. 2013 Nov;
93(1):81-8.
PMID: 24281161
The activating KIT D816V mutation plays a central role in the pathogenesis, diagnosis, and targeted treatment of systemic mastocytosis (SM). For improved and reliable identification of KIT D816V, we have...
2.
Nolte F, Giehl M, Haass W, Nowak V, Schumann C, Nowak D, et al.
Ann Hematol
. 2013 May;
92(10):1325-33.
PMID: 23645217
Centrosomes play important roles in the maintenance of genetic stability and centrosomal aberrations are a hallmark of cancer. Deregulation of centriole duplication leads to supernumerary centrosomes, sister chromatid missegregation and...
3.
Haass W, Stehle M, Nittka S, Giehl M, Schrotz-King P, Fabarius A, et al.
PLoS One
. 2012 Aug;
7(8):e42863.
PMID: 22870341
Separase, an endopeptidase required for the separation of sister-chromatides in mitotic anaphase, triggers centriole disengagement during centrosome duplication. In cancer, separase is frequently overexpressed, pointing to a functional role as...
4.
Gabriel U, Giehl M, Haass W, Trojan L, Michel M, Hofmann W, et al.
Cancer Genet Cytogenet
. 2010 Dec;
203(2):253-62.
PMID: 21156241
Tobacco smoke containing numerous derived chemical carcinogens is the main risk factor for urothelial carcinoma. These carcinogens can induce DNA damage leading to chromosomal instability, which plays a fundamental role...
5.
Giehl M, Leitner A, Haferlach C, Duesberg P, Hofmann W, Hofheinz R, et al.
Eur J Haematol
. 2010 Apr;
85(2):139-48.
PMID: 20408871
Objectives: Tyrosine kinase inhibitors (TKIs) target various pathways associated with proliferation of aberrant clones in malignant diseases. Despite good response and acceptable tolerability, little is known concerning long-term toxicity. Furthermore,...
6.
Fabarius A, Duesberg P, Giehl M, Seifarth W, Hochhaus A, Hehlmann R
Cell Oncol
. 2008 Oct;
30(6):503-4.
PMID: 18936527
No abstract available.
7.
Fabarius A, Giehl M, Rebacz B, Kramer A, Frank O, Haferlach C, et al.
Haematologica
. 2008 Jun;
93(8):1145-54.
PMID: 18519516
Background: Dasatinib is a multitargeted inhibitor of ABL, the SRC family, and other tyrosine kinases. We sought to evaluate the effects of this drug on cell proliferation, centrosomes, mitotic spindles,...
8.
Fabarius A, Giehl M, Frank O, Spiess B, Zheng C, Muller M, et al.
Br J Haematol
. 2007 Jul;
138(3):369-73.
PMID: 17614824
Centrosomes play fundamental roles in mitotic spindle organisation, chromosome segregation and maintenance of genetic stability. Recently, we have demonstrated that the tyrosine kinase inhibitor imatinib induces centrosome and chromosome aberrations...
9.
Fabarius A, Haferlach C, Muller M, Erben P, Lahaye T, Giehl M, et al.
Haematologica
. 2007 Jun;
92(6):834-7.
PMID: 17550857
Clonal cytogenetic aberrations of the Philadelphia chromosome (Ph) positive hematopoiesis have been associated with the natural evolution of chronic myeloid leukemia (CML) to advanced disease. Clonal aberrations of Ph negative...
10.
Frank O, Giehl M, Zheng C, Hehlmann R, Leib-Mosch C, Seifarth W
J Virol
. 2005 Aug;
79(17):10890-901.
PMID: 16103141
The detection and identification of retroviral transcripts in brain samples, cerebrospinal fluid, and plasma of individuals with recent-onset schizophrenia and schizoaffective disorders suggest that activation or upregulation of distinct human...