Michelle E Bishop
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Explore the profile of Michelle E Bishop including associated specialties, affiliations and a list of published articles.
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29
Citations
198
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Recent Articles
1.
Heflich R, Bishop M, Mittelstaedt R, Yan J, Guerrero S, Sims A, et al.
Regul Toxicol Pharmacol
. 2024 Sep;
153:105709.
PMID: 39343352
Accurately determining the mutagenicity of small-molecule N-nitrosamine drug impurities and nitrosamine drug substance-related impurities (NDSRIs) is critical to identifying mutagenic and cancer hazards. In the current study we have evaluated...
2.
Hu S, Min S, Kang H, Yang D, Basavarajappa M, Lewis S, et al.
Food Chem Toxicol
. 2021 Dec;
160:112780.
PMID: 34965465
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the key tobacco-specific nitrosamines that plays an important role in human lung carcinogenesis. Repeated dose inhalation toxicity data on NNK, particularly relevant to cigarette smoking,...
3.
Hu S, Min S, Kang H, Yang D, Lewis S, Davis K, et al.
Toxicol Sci
. 2021 Jul;
183(2):319-337.
PMID: 34329464
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the key tobacco-specific nitrosamines that plays an important role in human lung carcinogenesis. However, repeated inhalation toxicity data on NNK, which is more directly relevant...
4.
Hu S, Bryant M, Sepehr E, Kang H, Trbojevich R, Lagaud G, et al.
Toxicol Sci
. 2021 May;
182(1):10-28.
PMID: 33944952
The tobacco-specific nitrosamine NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone] is found in tobacco products and tobacco smoke. NNK is a potent genotoxin and human lung carcinogen; however, there are limited inhalation data for the...
5.
McKinzie P, Bishop M
Toxicol Sci
. 2019 Oct;
173(1):77-85.
PMID: 31621867
Quantifying mutant or variable allele frequencies (VAFs) of ≤10-3 using next-generation sequencing (NGS) has utility in both clinical and nonclinical settings. Two common approaches for quantifying VAFs using NGS are...
6.
McKinzie P, McKim K, Pearce M, Bishop M, Parsons B
Environ Mol Mutagen
. 2018 Sep;
59(8):715-721.
PMID: 30255594
Somatic mutations accumulate in the human genome and are correlated with increased cancer incidence as humans age. The standard model for studying the carcinogenic effects of exposures for human risk...
7.
Ding W, Bishop M, Lyn-Cook L, Davis K, Manjanatha M
J Vis Exp
. 2016 May;
(111).
PMID: 27166647
Unrepaired DNA damage can lead to genetic instability, which in turn may enhance cancer development. Therefore, identifying potential DNA damaging agents is important for protecting public health. The in vivo...
8.
Ding W, Bishop M, Pearce M, Davis K, White G, Lyn-Cook L, et al.
Mutat Res Genet Toxicol Environ Mutagen
. 2014 Dec;
774:1-7.
PMID: 25440904
Cyproterone acetate (CPA), a synthetic hormonal drug, induces rat liver tumors in a sex-specific manner, with five-fold higher doses needed to induce liver tumors in male rats compared to females....
9.
Ding W, Levy D, Bishop M, Pearce M, Davis K, Jeffrey A, et al.
Environ Mol Mutagen
. 2014 Nov;
56(4):356-65.
PMID: 25361439
Estragole, a naturally occurring constituent of various herbs and spices, is a rodent liver carcinogen which requires bio-activation. To further understand the mechanisms underlying its carcinogenicity, genotoxicity was assessed in...
10.
Manjanatha M, Bishop M, Pearce M, Kulkarni R, Lyn-Cook L, Ding W
Environ Mol Mutagen
. 2013 Oct;
55(1):24-34.
PMID: 24155181
Doxorubicin (DOX) is an antineoplastic drug effective against many human malignancies. DOX's clinical efficacy is greatly limited because of severe cardiotoxicity. To evaluate if DOX is genotoxic in the heart,...