Michelle D Leach
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Explore the profile of Michelle D Leach including associated specialties, affiliations and a list of published articles.
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22
Citations
881
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Recent Articles
1.
Caplan T, Polvi E, Xie J, Buckhalter S, Leach M, Robbins N, et al.
Cell Rep
. 2018 May;
23(8):2292-2298.
PMID: 29791841
Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is readily acquired via...
2.
Xie J, Bohovych I, Wong E, Lambert J, Gingras A, Khalimonchuk O, et al.
Microb Cell
. 2017 Oct;
4(10):342-361.
PMID: 29082232
Mitochondria underpin metabolism, bioenergetics, signalling, development and cell death in eukaryotes. Most of the ~1,000 yeast mitochondrial proteins are encoded in the nucleus and synthesised as precursors in the cytosol,...
3.
Xie J, Qin L, Miao Z, Grys B, De La Cruz Diaz J, Ting K, et al.
Nat Commun
. 2017 Sep;
8(1):499.
PMID: 28894103
The capacity to coordinate environmental sensing with initiation of cellular responses underpins microbial survival and is crucial for virulence and stress responses in microbial pathogens. Here we define circuitry that...
4.
Leach M, Kim T, DiGregorio S, Collins C, Zhang Z, Duennwald M, et al.
G3 (Bethesda)
. 2016 Nov;
7(1):95-108.
PMID: 27807047
Disruption of protein quality control can be detrimental, having toxic effects on single cell organisms and contributing to neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's in humans. Here, we...
5.
Xie J, Grahl N, Sless T, Leach M, Kim S, Hogan D, et al.
PLoS Genet
. 2016 Oct;
12(10):e1006405.
PMID: 27788136
The capacity to transition between distinct morphological forms is a key virulence trait for diverse fungal pathogens. A poignant example of a leading opportunistic fungal pathogen of humans for which...
6.
Leach M, Farrer R, Tan K, Miao Z, Walker L, Cuomo C, et al.
Nat Commun
. 2016 May;
7:11704.
PMID: 27226156
Fever is a universal response to infection, and opportunistic pathogens such as Candida albicans have evolved complex circuitry to sense and respond to heat. Here we harness RNA-seq and ChIP-seq...
7.
Diezmann S, Leach M, Cowen L
PLoS One
. 2015 Sep;
10(9):e0137947.
PMID: 26367740
Candida albicans is among the most prevalent opportunistic fungal pathogens. Its capacity to cause life-threatening bloodstream infections is associated with the ability to form biofilms, which are intrinsically drug resistant...
8.
Polvi E, Li X, OMeara T, Leach M, Cowen L
Cell Mol Life Sci
. 2015 Feb;
72(12):2261-87.
PMID: 25700837
Life-threatening invasive fungal infections are becoming increasingly common, at least in part due to the prevalence of medical interventions resulting in immunosuppression. Opportunistic fungal pathogens of humans exploit hosts that...
9.
Sandai D, Yin Z, Selway L, Stead D, Walker J, Leach M, et al.
mBio
. 2015 Jan;
6(1).
PMID: 25604791
No abstract available.
10.
Leach M, Cowen L
Eukaryot Cell
. 2014 Jun;
13(8):1077-84.
PMID: 24951438
Temperature is a ubiquitous environmental variable which can profoundly influence the physiology of living cells as it changes over time and space. When yeast cells are exposed to a sublethal...