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Michele Simonato

Explore the profile of Michele Simonato including associated specialties, affiliations and a list of published articles. Areas
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Articles 104
Citations 1971
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Recent Articles
1.
van Vliet E, Scheper M, Mills J, Puhakka N, Szydlowska K, Ferracin M, et al.
Epilepsia . 2024 Oct; 65(11):3406-3420. PMID: 39352406
Objective: Structural epilepsies can manifest months or years after the occurrence of an initial epileptogenic insult, making them amenable for secondary prevention. However, development of preventive treatments has been challenged...
2.
Cattaneo S, Bettegazzi B, Crippa L, Asth L, Regoni M, Soukupova M, et al.
EMBO Rep . 2024 Sep; 25(10):4387-4409. PMID: 39251828
Gene therapy is emerging as an alternative option for individuals with drug-resistant focal epilepsy. Here, we explore the potential of a novel gene therapy based on Neuropeptide Y (NPY), a...
3.
Guarino A, Pignata P, Lovisari F, Asth L, Simonato M, Soukupova M
Front Neurol . 2024 Jun; 15:1392977. PMID: 38872822
Patients with epilepsy are prone to cognitive decline, depression, anxiety and other behavioral disorders. Cognitive comorbidities are particularly common and well-characterized in people with temporal lobe epilepsy, while inconsistently addressed...
4.
Aziz N, Ruzza C, Falcicchia C, Guarino A, Soukupova M, Asth L, et al.
Int J Mol Sci . 2024 Apr; 25(8). PMID: 38673746
Neuroinflammation is associated with several neurological disorders including temporal lobe epilepsy. Seizures themselves can induce neuroinflammation. In an in vivo model of epilepsy, the supplementation of brain-derived neurotropic factor (BDNF)...
5.
Bettegazzi B, Cattaneo S, Simonato M, Zucchini S, Soukupova M
Mol Diagn Ther . 2023 Dec; 28(1):5-13. PMID: 38103141
In recent years, many pre-clinical studies have tested gene therapy approaches as possible treatments for epilepsy, following the idea that they may provide an alternative to conventional pharmacological and surgical...
6.
Soukupova M, Guarino A, Asth L, Marino P, Barbieri M, Simonato M, et al.
J Vis Exp . 2023 Sep; (199). PMID: 37677021
Because the composition of body fluids reflects many physiological and pathological dynamics, biological liquid samples are commonly obtained in many experimental contexts to measure molecules of interest, such as hormones,...
7.
Henshall D, Arzimanoglou A, Dedeurwaerdere S, Guerrini R, Jozwiak S, Kokaia M, et al.
Epilepsy Res . 2022 Dec; 189:107068. PMID: 36549242
Collaboration is essential to the conduct of basic, applied and clinical research and its translation into the technologies and treatments urgently needed to improve the lives of people living with...
8.
Guarino A, Bettegazzi B, Aziz N, Barbieri M, Bochicchio D, Crippa L, et al.
Neurotherapeutics . 2022 Sep; 19(6):1951-1965. PMID: 36180719
Temporal lobe epilepsy often manifests months or even years after an initial epileptogenic insult (e.g., stroke, trauma, status epilepticus) and, therefore, may be preventable. However, no such preventive treatment is...
9.
Henshall D, Guerrini R, Jozwiak S, Kokaia M, Pitkanen A, Sisodiya S, et al.
Epilepsy Res . 2021 Nov; 178:106811. PMID: 34814066
No abstract available.
10.
Patergnani S, Bonora M, Ingusci S, Previati M, Marchi S, Zucchini S, et al.
Proc Natl Acad Sci U S A . 2021 Jun; 118(24). PMID: 34099564
Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease characterized by myelin damage followed by axonal and ultimately neuronal loss. The etiology and physiopathology of MS are still elusive, and...