Michele Dargis
Overview
Explore the profile of Michele Dargis including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
402
Followers
0
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Recent Articles
1.
Shapiro J, Andreani G, Dube C, Berube M, Bussiere D, Couture M, et al.
Vaccine
. 2023 Aug;
41(41):6008-6016.
PMID: 37625992
Background: Norovirus (NoV) is the most common cause of diarrheal episodes globally. Issues with in vitro cultivation systems, genetic variation, and animal models have hindered vaccine development. Plant-derived virus-like particles...
2.
Kurokawa N, Robinson M, Bernard C, Kawaguchi Y, Koujin Y, Koen A, et al.
Vaccine
. 2021 Aug;
39(39):5513-5523.
PMID: 34454786
Background: This study is the first clinical trial for a parenteral non-replicating rotavirus vaccine developed using virus-like particle (VLP) technology. Methods: This open-labeled, randomized, placebo-controlled trial was conducted in two...
3.
Kurokawa N, Lavoie P, DAoust M, Couture M, Dargis M, Trepanier S, et al.
Vaccine
. 2021 Jul;
39(35):4979-4987.
PMID: 34325930
Background: Virus-like particles (VLPs) are unable to replicate in the recipient but stimulate the immune system through recognition of repetitive subunits. Parenterally delivered rotavirus-VLP (Ro-VLP) vaccine could have the potential...
4.
Pillet S, Aubin E, Trepanier S, Bussiere D, Dargis M, Poulin J, et al.
Clin Immunol
. 2016 Mar;
168:72-87.
PMID: 26987887
Recent issues regarding efficacy of influenza vaccines have re-emphasized the need of new approaches to face this major public health issue. In a phase 1-2 clinical trial, healthy adults received...
5.
Ward B, Landry N, Trepanier S, Mercier G, Dargis M, Couture M, et al.
Vaccine
. 2014 Sep;
32(46):6098-106.
PMID: 25240757
Background: Plant-made biotherapeutics are gathering momentum and some plant glycoproteins are allergens. Glycans with core β1-2xylose and α1,3fucose motifs and antennae terminated by mannose residues (e.g.: MMXF) are found on...
6.
Landry N, Ward B, Trepanier S, Montomoli E, Dargis M, Lapini G, et al.
PLoS One
. 2011 Jan;
5(12):e15559.
PMID: 21203523
Unlabelled: The recent swine H1N1 influenza outbreak demonstrated that egg-based vaccine manufacturing has an Achille's heel: its inability to provide a large number of doses quickly. Using a novel manufacturing...
7.
DAoust M, Lavoie P, Couture M, Trepanier S, Guay J, Dargis M, et al.
Plant Biotechnol J
. 2008 Dec;
6(9):930-40.
PMID: 19076615
A strain-specific vaccine represents the best possible response to the threat of an influenza pandemic. Rapid delivery of such a vaccine to the world's population before the peak of the...
8.
Bardor M, Loutelier-Bourhis C, Paccalet T, Cosette P, Fitchette A, Vezina L, et al.
Plant Biotechnol J
. 2006 Dec;
1(6):451-62.
PMID: 17134403
Structural analysis of the N-glycosylation of alfalfa proteins was investigated in order to evaluate the capacity of this plant to perform this biologically important post-translational modification. We show that, in...