Michele D Binder
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Explore the profile of Michele D Binder including associated specialties, affiliations and a list of published articles.
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32
Citations
456
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Recent Articles
1.
Atkin-Smith G, Santavanond J, Light A, Rimes J, Samson A, Er J, et al.
Nat Commun
. 2024 Oct;
15(1):8802.
PMID: 39438460
Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly exposed to a variety of molecular factors and...
2.
Li V, Binder M, Purcell A, Kilpatrick T
J Neuroimmunol
. 2024 Apr;
390:578347.
PMID: 38663308
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system resulting from loss of immune tolerance. Many disease-modifying therapies for MS have broad immunosuppressive effects on...
3.
Asadian N, Aprico A, Chen M, Yuen D, Johnston A, Kilpatrick T, et al.
Glia
. 2024 Apr;
72(8):1392-1401.
PMID: 38572807
Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) characterized by demyelination, axonal damage and, for the majority of people, a decline in neurological function in the...
4.
Binder M, Nwoke E, Morwitch E, Dwyer C, Li V, Xavier A, et al.
Neurol Neuroimmunol Neuroinflamm
. 2023 Dec;
11(2):e200190.
PMID: 38150649
Background And Objectives: HLA-DRB1*15:01 (DR15) and are 2 risk genes for multiple sclerosis (MS). The variant rs7422195 is an expression quantitative trait locus for MERTK in CD14 monocytes; cells with...
5.
Li V, Binder M, Kilpatrick T
Int J Mol Sci
. 2023 Nov;
24(21).
PMID: 37958886
Many treatments for autoimmune diseases, caused by the loss of immune self-tolerance, are broadly immunosuppressive. Dendritic cells (DCs) can be induced to develop anti-inflammatory/tolerogenic properties to suppress aberrant self-directed immunity...
6.
Nguyen L, Aprico A, Nwoke E, Walsh A, Blades F, Avneri R, et al.
J Neuroinflammation
. 2023 Nov;
20(1):253.
PMID: 37926818
Background: Microglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and colonise all regions of the CNS early in...
7.
Walsh A, Stone S, Freytag S, Aprico A, Kilpatrick T, Ansell B, et al.
Commun Biol
. 2023 May;
6(1):555.
PMID: 37217597
Microglia regulate multiple processes in the central nervous system, exhibiting a considerable level of cellular plasticity which is facilitated by an equally dynamic transcriptional environment. While many gene networks that...
8.
Thivisol U, Binder M, Hannan A, Pang T
Brain Res
. 2023 Mar;
1807:148319.
PMID: 36898476
White-matter brain abnormalities have been found across a variety of psychiatric disorders. The extent of white matter pathology is proposed to be predictive of the severity of anxiety disorders. However,...
9.
Medeiros-Furquim T, Ayoub S, Johnson L, Aprico A, Nwoke E, Binder M, et al.
Front Immunol
. 2022 Jun;
13:678817.
PMID: 35734180
Cladribine (2-chlorodeoxyadenosine, 2CdA) is one of the most effective disease-modifying drugs for multiple sclerosis (MS). Cladribine is a synthetic purine nucleoside analog that induces cell death of lymphocytes and oral...
10.
Blades F, Chambers J, Aumann T, Nguyen C, Wong V, Aprico A, et al.
Brain Struct Funct
. 2022 Apr;
227(6):2035-2048.
PMID: 35441271
Myelination within the central nervous system (CNS) is crucial for the conduction of action potentials by neurons. Variation in compact myelin morphology and the structure of the paranode are hypothesised...