Michele Benedetti
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Explore the profile of Michele Benedetti including associated specialties, affiliations and a list of published articles.
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54
Citations
222
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Recent Articles
11.
Castro F, Ciardullo G, Fanizzi F, Prejano M, Benedetti M, Marino T
Int J Mol Sci
. 2023 Jun;
24(12).
PMID: 37372996
In this work, we elucidated some key aspects of the mechanism of action of the cisplatin anticancer drug, -[Pt(NH)Cl], involving direct interactions with free nucleotides. A comprehensive in silico molecular...
12.
Castro F, Stefano E, De Luca E, Benedetti M, Fanizzi F
Pharmaceutics
. 2023 Mar;
15(3).
PMID: 36986802
Nucleoside analogues (NAs) are a family of compounds which include a variety of purine and pyrimidine derivatives, widely used as anticancer and antiviral agents. For their ability to compete with...
13.
Catarci M, Guadagni S, Masedu F, Montemurro L, Ciano P, Benedetti M, et al.
Diagnostics (Basel)
. 2023 Mar;
13(5).
PMID: 36900095
Blood transfusions are considered a risk factor for adverse outcomes after colorectal surgery. However, it is still unclear if they are the cause (the hen) or the consequence (the egg)...
14.
Castro F, Stefano E, De Luca E, Muscella A, Marsigliante S, Benedetti M, et al.
Bioinorg Chem Appl
. 2022 Jun;
2022:8932137.
PMID: 35721691
NMR-based metabolomics is a very effective tool to assess the tumor response to drugs by providing insights for their mode of action. Recently, a novel Pt(II) complex, [Pt(ƞ-CHOMe)(DMSO)(phen)] (phen = ...
15.
Stefano E, Muscella A, Benedetti M, Castro F, Fanizzi F, Marsigliante S
Biochem Pharmacol
. 2022 Jun;
202:115124.
PMID: 35688179
Among the new Pt complexes with anticancer properties, phenanthroline derivatives have aroused great interest due to their different mode of action compared to cisplatin. We previously examined cytotoxic effects of...
16.
Castro F, Vergaro V, Benedetti M, Baldassarre F, Del Coco L, DellAnna M, et al.
ACS Appl Bio Mater
. 2022 Jan;
3(10):6836-6851.
PMID: 35019346
Nanoparticle-based drug delivery systems for cancer therapy offer a great promising opportunity as they specifically target cancer cells, also increasing the bioavailability of anticancer drugs characterized by low water solubility....
17.
Castro F, De Luca E, Girelli C, Barca A, Romano A, Migoni D, et al.
J Inorg Biochem
. 2021 Nov;
226:111660.
PMID: 34801970
Nucleos(t)ide analogues (NA) belong to a family of compounds widely used in anticancer/antiviral treatments. They generally exhibit a cell toxicity limited by cellular uptake levels and the resulting nucleos(t)ides metabolism...
18.
Castro F, Stefano E, Migoni D, Iaconisi G, Muscella A, Marsigliante S, et al.
Pharmaceutics
. 2021 May;
13(5).
PMID: 33946459
Starting from the [PtCl(η-CHOMe)(phen)] (phen = 1,10-phenanthroline, ) platinum(II) precursor, we synthesized and characterized by multinuclear NMR new [Pt(η-CHOMe)(L)(phen)] (L = NH, ; DMSO, ) complexes. These organometallic species, potentially...
19.
Germani P, Di Candido F, Leonard D, Cuicchi D, Elmore U, Allaix M, et al.
Updates Surg
. 2021 Apr;
73(5):1795-1803.
PMID: 33818750
Pre-operative chemoradiotherapy (CRT) followed by surgical resection is still the standard treatment for locally advanced low rectal cancer. Nowadays new strategies are emerging to treat patients with a complete response...
20.
Catarci M, Maurizi A, Benedetti M, Giachetta A, Ciotti S, Spinelli F, et al.
Recenti Prog Med
. 2021 Jan;
112(1):30-44.
PMID: 33512357
Background: An Enhanced Recovery After Surgery (ERAS) program in colorectal surgery is able to significantly reduce the morbidity rates and postoperative hospital stay (LOS) related to the intervention. However, it...