Michele A Cleary
Overview
Explore the profile of Michele A Cleary including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
4248
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Recent Articles
21.
Qi J, Yu J, Shcherbata H, Mathieu J, Wang A, Seal S, et al.
Cell Cycle
. 2009 Oct;
8(22):3729-41.
PMID: 19823043
microRNAs (miRNAs) regulate numerous physiological processes such as cell division and differentiation in many tissue types including stem cells. To probe the role that miRNAs play in regulating processes relevant...
22.
Klinghoffer R, Frazier J, Annis J, Berndt J, Roberts B, Arthur W, et al.
PLoS One
. 2009 Sep;
4(9):e6892.
PMID: 19727391
The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is...
23.
Zhang Z, Sun H, Dai H, Walsh R, Imakura M, Schelter J, et al.
Cell Cycle
. 2009 Aug;
8(17):2756-68.
PMID: 19652553
The hypoxia-inducible factor (HIF) pathway is essential for cell survival under low oxygen and plays an important role in tumor cell homeostasis. We investigated the function of miR-210, the most...
24.
James R, Biechele T, Conrad W, Camp N, Fass D, Major M, et al.
Sci Signal
. 2009 May;
2(72):ra25.
PMID: 19471023
Wnts are secreted ligands that activate several receptor-mediated signal transduction cascades. Homeostatic Wnt signaling through beta-catenin is required in adults, because either elevation or attenuation of beta-catenin function has been...
25.
Chau B, Diaz R, Saunders M, Cheng C, Chang A, Warrener P, et al.
Cancer Res
. 2009 Feb;
69(4):1368-74.
PMID: 19190338
Microarray analysis has been useful for identifying the targets of many transcription factors. However, gene expression changes in response to transcription factor perturbation reveal both direct transcriptional targets and secondary...
26.
Georges S, Biery M, Kim S, Schelter J, Guo J, Chang A, et al.
Cancer Res
. 2008 Dec;
68(24):10105-12.
PMID: 19074876
Cell cycle arrest in response to DNA damage is an important antitumorigenic mechanism. MicroRNAs (miRNAs) were recently shown to play key regulatory roles in cell cycle progression. For example, miR-34a...
27.
Babak T, Deveale B, Armour C, Raymond C, Cleary M, van der Kooy D, et al.
Curr Biol
. 2008 Nov;
18(22):1735-41.
PMID: 19026546
Genomic imprinting restricts gene expression to a paternal or maternal allele. To date, approximately 90 imprinted transcripts have been identified in mouse, of which the majority were detected after intense...
28.
Major M, Roberts B, Berndt J, Marine S, Anastas J, Chung N, et al.
Sci Signal
. 2008 Nov;
1(45):ra12.
PMID: 19001663
The identification and characterization of previously unidentified signal transduction molecules has expanded our understanding of biological systems and facilitated the development of mechanism-based therapeutics. We present a highly validated small...
29.
Ivanovska I, Cleary M
Cell Cycle
. 2008 Oct;
7(20):3137-42.
PMID: 18927506
MicroRNAs regulate gene networks and therefore are inherently complex. MicroRNAs themselves function in networks of other microRNAs, some of which are co-expressed from the same locus. To better understand the...
30.
Chung E, Dews M, Cozma D, Yu D, Wentzel E, Chang T, et al.
Cancer Biol Ther
. 2008 Aug;
7(11):1758-64.
PMID: 18708755
The dleu2 tumor suppressor locus encodes two microRNAs, miR-15a and miR-16, which are thought to play an important role in B-cell neoplasms. However, relatively little is known about proteins that...