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» Authors » Michel R Klein

Michel R Klein

Explore the profile of Michel R Klein including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 24
Citations 1039
Followers 0
Related Specialties
Allergy & Immunology
Microbiology
Science
Top 10 Co-Authors
Tom H M Ottenhoff
Kees L M C Franken
Krista E van Meijgaarden
May Young Lin
Annemieke Geluk
Annemieke H Friggen
Gillian F Black
Shreemanta K Parida
Gerhard Walzl
Stefan H E Kaufmann
Published In
Infect Immun
PLoS One
Microbes Infect
Vaccine
J Infect Dis
Affiliations
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Recent Articles
1.
Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa
Sutherland J, Lalor M, Black G, Ambrose L, Loxton A, Chegou N, et al.
PLoS One . 2013 Sep; 8(9):e74080. PMID: 24040170
Background: Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define...
2.
Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area
Chegou N, Essone P, Loxton A, Stanley K, Black G, van der Spuy G, et al.
PLoS One . 2012 Jun; 7(6):e38501. PMID: 22693640
Background: Recent interferon gamma (IFN-γ)-based studies have identified novel Mycobacterium tuberculosis (M.tb) infection phase-dependent antigens as diagnostic candidates. In this study, the levels of 11 host markers other than IFN-γ,...
3.
Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting
Chegou N, Black G, Loxton A, Stanley K, Essone P, Klein M, et al.
BMC Infect Dis . 2012 Jan; 12:10. PMID: 22260319
Background: Confirming tuberculosis (TB) disease in suspects in resource limited settings is challenging and calls for the development of more suitable diagnostic tools. Different Mycobacterium tuberculosis (M.tb) infection phase-dependent antigens...
4.
Genome-based in silico identification of new Mycobacterium tuberculosis antigens activating polyfunctional CD8+ T cells in human tuberculosis
Tang S, van Meijgaarden K, Caccamo N, Guggino G, Klein M, van Weeren P, et al.
J Immunol . 2010 Dec; 186(2):1068-80. PMID: 21169544
Although CD8(+) T cells help control Mycobacterium tuberculosis infection, their M. tuberculosis Ag repertoire, in vivo frequency, and functionality in human tuberculosis (TB) remains largely undefined. We have performed genome-based...
5.
Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers
van Dissel J, Arend S, Prins C, Bang P, Tingskov P, Lingnau K, et al.
Vaccine . 2010 Mar; 28(20):3571-81. PMID: 20226890
Though widely used, the BCG vaccine has had little apparent effect on rates of adult pulmonary tuberculosis. Moreover, the risk of disseminated BCG disease in immunocompromised individuals means that improved...
6.
Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity
Joosten S, van Meijgaarden K, van Weeren P, Kazi F, Geluk A, Savage N, et al.
PLoS Pathog . 2010 Mar; 6(2):e1000782. PMID: 20195504
Tuberculosis (TB) is an escalating global health problem and improved vaccines against TB are urgently needed. HLA-E restricted responses may be of interest for vaccine development since HLA-E displays very...
7.
Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria
Lin M, Reddy T, Arend S, Friggen A, Franken K, van Meijgaarden K, et al.
Infect Immun . 2009 Sep; 77(11):5071-9. PMID: 19737909
Mycobacterium tuberculosis DosR regulon-encoded antigens are highly immunogenic in M. tuberculosis-infected humans and are associated with latent tuberculosis infection. We have investigated the hypothesis that infection with or exposure to...
8.
Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa
Black G, Thiel B, Ota M, Parida S, Adegbola R, Boom W, et al.
Clin Vaccine Immunol . 2009 Jun; 16(8):1203-12. PMID: 19553548
Increasing knowledge about DosR regulon-encoded proteins has led us to produce novel Mycobacterium tuberculosis antigens for immunogenicity testing in human populations in three countries in Africa to which tuberculosis (TB)...
9.
Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in patients with active tuberculosis and in individuals with latent infection
Caccamo N, Guggino G, Meraviglia S, Gelsomino G, Di Carlo P, Titone L, et al.
PLoS One . 2009 May; 4(5):e5528. PMID: 19436760
CD8 T-cells contribute to control of Mycobacterium tuberculosis infection, but little is known about the quality of the CD8 T-cell response in subjects with latent infection and in patients with...
10.
Pulmonary delivery of DNA encoding Mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA-PEI nanoparticles enhances T cell responses in a DNA prime/protein boost vaccination regimen in mice
Bivas-Benita M, Lin M, Bal S, van Meijgaarden K, Franken K, Friggen A, et al.
Vaccine . 2009 Apr; 27(30):4010-7. PMID: 19389445
During persistent infection and hypoxic-stress, Mycobacterium tuberculosis (Mtb) expresses a series of Mtb latency antigens. The aim of this study was to evaluate the immunogenicity of a DNA vaccine encoding...