Michal Nadler-Holly
Overview
Explore the profile of Michal Nadler-Holly including associated specialties, affiliations and a list of published articles.
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12
Citations
252
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Recent Articles
1.
Morgan J, Singh A, Kurz L, Nadler-Holly M, Ruwolt M, Ganguli S, et al.
Nat Chem Biol
. 2024 Apr;
20(10):1305-1316.
PMID: 38664588
Reversible protein phosphorylation is a central signaling mechanism in eukaryotes. Although mass-spectrometry-based phosphoproteomics has become routine, identification of non-canonical phosphorylation has remained a challenge. Here we report a tailored workflow...
2.
Jang W, Puchkov D, Samso P, Liang Y, Nadler-Holly M, Sigrist S, et al.
Science
. 2022 Dec;
378(6625):eabq5209.
PMID: 36520888
Cells respond to fluctuating nutrient supply by adaptive changes in organelle dynamics and in metabolism. How such changes are orchestrated on a cell-wide scale is unknown. We show that endosomal...
3.
Alborzinia H, Florez A, Kreth S, Bruckner L, Yildiz U, Gartlgruber M, et al.
Nat Cancer
. 2022 Apr;
3(4):471-485.
PMID: 35484422
Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance....
4.
Ruwolt M, Schnirch L, Lima D, Nadler-Holly M, Viner R, Liu F
Anal Chem
. 2022 Mar;
94(13):5265-5272.
PMID: 35290030
Cross-linking mass spectrometry (XL-MS) is a powerful method for the investigation of protein-protein interactions (PPI) from highly complex samples. XL-MS combined with tandem mass tag (TMT) labeling holds the promise...
5.
Dorel M, Klinger B, Mari T, Toedling J, Blanc E, Messerschmidt C, et al.
PLoS Comput Biol
. 2021 Nov;
17(11):e1009515.
PMID: 34735429
Very high risk neuroblastoma is characterised by increased MAPK signalling, and targeting MAPK signalling is a promising therapeutic strategy. We used a deeply characterised panel of neuroblastoma cell lines and...
6.
Hartlieb S, Sieverling L, Nadler-Holly M, Ziehm M, Toprak U, Herrmann C, et al.
Nat Commun
. 2021 Feb;
12(1):1269.
PMID: 33627664
Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas...
7.
Furkert D, Nadler-Holly M, Fiedler D
STAR Protoc
. 2021 Jan;
2(1):100277.
PMID: 33490990
This protocol describes an affinity enrichment approach from mammalian cell extracts to identify protein binding partners of inositol hexakisphosphate (InsP) and 5-diphosphoinositol pentakisphosphate (5PP-InsP), two important eukaryotic metabolites. The interactomes...
8.
Furkert D, Hostachy S, Nadler-Holly M, Fiedler D
Cell Chem Biol
. 2020 Aug;
27(8):1097-1108.e4.
PMID: 32783964
The inositol pyrophosphates (PP-InsPs) are a ubiquitous group of highly phosphorylated eukaryotic messengers. They have been linked to a panoply of central cellular processes, but a detailed understanding of the...
9.
Schnirch L, Nadler-Holly M, Siao S, Frese C, Viner R, Liu F
Anal Chem
. 2020 Jul;
92(15):10495-10503.
PMID: 32643919
In cross-linking mass spectrometry (XL-MS), the depth and sensitivity of cross-link detection is often limited by the low abundance of cross-links compared to non-cross-linked peptides in the digestion mixture. To...
10.
Korobko I, Nadler-Holly M, Horovitz A
J Mol Biol
. 2016 Oct;
428(22):4520-4527.
PMID: 27686496
The chaperonin-containing t-complex polypeptide 1 (CCT, also known as TRiC) assists protein folding in an ATP-dependent manner. CCT/TRiC was mixed rapidly with different concentrations of ATP, and the amount of...