Michal H Mudd
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Explore the profile of Michal H Mudd including associated specialties, affiliations and a list of published articles.
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11
Citations
825
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Recent Articles
1.
Javed R, Mari M, Trosdal E, Duque T, Paddar M, Allers L, et al.
J Cell Biol
. 2025 Jan;
224(2).
PMID: 39745851
Canonical autophagy captures within specialized double-membrane organelles, termed autophagosomes, an array of cytoplasmic components destined for lysosomal degradation. An autophagosome is completed when the growing phagophore undergoes ESCRT-dependent membrane closure,...
2.
Kumar S, Jain A, Choi S, da Silva G, Allers L, Mudd M, et al.
Autophagy
. 2020 Oct;
16(12):2305-2306.
PMID: 33070669
Macroautophagy/autophagy delivers cytoplasmic cargo to lysosomes for degradation. In yeast, the single Atg8 protein plays a role in the formation of autophagosomes whereas in mammalian cells there are five to...
3.
Kumar S, Jain A, Choi S, da Silva G, Allers L, Mudd M, et al.
Nat Cell Biol
. 2020 Aug;
22(10):1286.
PMID: 32788721
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
4.
Kumar S, Jain A, Choi S, da Silva G, Allers L, Mudd M, et al.
Nat Cell Biol
. 2020 Aug;
22(8):973-985.
PMID: 32753672
Autophagy is a homeostatic process with multiple functions in mammalian cells. Here, we show that mammalian Atg8 proteins (mAtg8s) and the autophagy regulator IRGM control TFEB, a transcriptional activator of...
5.
Jia J, Claude-Taupin A, Gu Y, Choi S, Peters R, Bissa B, et al.
Autophagy
. 2020 Jun;
16(8):1539-1541.
PMID: 32521192
Abbreviations: AMPK: AMP-activated protein kinase; APEX2: engineered ascorbate peroxidase 2; ATG13: autophagy related 13; ATG16L1: autophagy related 16 like 1; BMMs: bone marrow-derived macrophages; ESCRT: endosomal sorting complexes required for...
6.
Jia J, Claude-Taupin A, Gu Y, Choi S, Peters R, Bissa B, et al.
Dev Cell
. 2019 Dec;
52(1):69-87.e8.
PMID: 31813797
Endomembrane damage elicits homeostatic responses including ESCRT-dependent membrane repair and autophagic removal of damaged organelles. Previous studies have suggested that these systems may act separately. Here, we show that galectin-3...
7.
Jia J, Abudu Y, Claude-Taupin A, Gu Y, Kumar S, Choi S, et al.
Autophagy
. 2018 Aug;
15(1):169-171.
PMID: 30081722
The Ser/Thr protein kinase MTOR (mechanistic target of rapamycin kinase) regulates cellular metabolism and controls macroautophagy/autophagy. Autophagy has both metabolic and quality control functions, including recycling nutrients at times of...
8.
Jia J, Abudu Y, Claude-Taupin A, Gu Y, Kumar S, Choi S, et al.
Mol Cell
. 2018 Apr;
70(1):120-135.e8.
PMID: 29625033
The Ser/Thr protein kinase mTOR controls metabolic pathways, including the catabolic process of autophagy. Autophagy plays additional, catabolism-independent roles in homeostasis of cytoplasmic endomembranes and whole organelles. How signals from...
9.
Kumar S, Jain A, Farzam F, Jia J, Gu Y, Choi S, et al.
J Cell Biol
. 2018 Feb;
217(3):997-1013.
PMID: 29420192
Autophagy is a conserved eukaryotic process with metabolic, immune, and general homeostatic functions in mammalian cells. Mammalian autophagosomes fuse with lysosomes in a SNARE-driven process that includes syntaxin 17 (Stx17)....
10.
Chauhan S, Kumar S, Jain A, Ponpuak M, Mudd M, Kimura T, et al.
Dev Cell
. 2016 Oct;
39(1):13-27.
PMID: 27693506
Selective autophagy performs an array of tasks to maintain intracellular homeostasis, sterility, and organellar and cellular functionality. The fidelity of these processes depends on precise target recognition and limited activation...