Michal Chodynski
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Explore the profile of Michal Chodynski including associated specialties, affiliations and a list of published articles.
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20
Citations
162
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Recent Articles
11.
Corcoran A, Bermudez M, Seoane S, Perez-Fernandez R, Krupa M, Pietraszek A, et al.
J Steroid Biochem Mol Biol
. 2015 Oct;
164:66-71.
PMID: 26429396
1,25-dihydroxyvitamin D (1,25D), a steroid hormone which regulates calcium/phosphate homeostasis, has a broad spectrum of anti-cancer activities, including differentiation of acute myeloid leukemia (AML) cells. In order to avoid undesirable...
12.
Bolla N, Corcoran A, Yasuda K, Chodynski M, Krajewski K, Cmoch P, et al.
J Steroid Biochem Mol Biol
. 2015 Sep;
164:50-55.
PMID: 26321387
An improved convergent strategy was developed for the synthesis of the previously obtained side-chain extended and rigidified analogs of 1α,25-dihydroxyvitamin D, PRI-1906 and PRI-1907. New (24Z) geometric isomers of the...
13.
Nadkarni S, Chodynski M, Krajewski K, Cmoch P, Marcinkowska E, Brown G, et al.
J Steroid Biochem Mol Biol
. 2015 Aug;
164:45-49.
PMID: 26316152
There is a long lasting controversy over the biological activity of vitamin D as compared to vitamin D in terms of maintaining of calcium homeostasis and raising the level of...
14.
Nadkarni S, Chodynski M, Corcoran A, Marcinkowska E, Brown G, Kutner A
Curr Pharm Des
. 2014 Dec;
21(13):1741-63.
PMID: 25483861
Rational design, chemical synthesis, structural analysis, molecular modeling and biological evaluation are reviewed for all the double point modified vitamin D analogs that have been developed as potential therapeutics over...
15.
Milczarek M, Chodynski M, Filip-Psurska B, Martowicz A, Krupa M, Krajewski K, et al.
Cancers (Basel)
. 2013 Nov;
5(4):1355-78.
PMID: 24202449
Diastereomeric and geometric analogs of calcipotriol, PRI-2202 and PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones and side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2201)...
16.
Pietraszek A, Malinska M, Chodynski M, Martynow J, Krupa M, Maruszak W, et al.
J Pharm Sci
. 2013 Aug;
102(11):3925-31.
PMID: 23946154
As predicted by single crystal X-ray crystallography, and contrary to the reported suggestions, the anhydrous form of calcipotriol, a therapeutically important vitamin D analog, was found stable enough to be...
17.
Pietraszek A, Malinska M, Chodynski M, Krupa M, Krajewski K, Cmoch P, et al.
Steroids
. 2013 Jul;
78(10):1003-14.
PMID: 23811018
The hybrid analogs of 1,25-dihydroxyergocalciferol (PRI-5201 and PRI-5202) were synthesized as potential anticancer agents using a convergent strategy. The analogs were designed by combining a 19-nor modification of the A-ring...
18.
Dams I, Chodynski M, Krupa M, Pietraszek A, Zezula M, Cmoch P, et al.
Chirality
. 2013 Feb;
25(3):170-9.
PMID: 23381781
The 17-phenyl PGF(2α) analogue bimatoprost (10a) is the most efficacious ocular hypotensive agent currently available for the treatment of glaucoma or ocular hypertension. A novel convergent synthesis of 13,14-en-15-ol prostamideF(2α)...
19.
Wietrzyk J, Chodynski M, Fitak H, Wojdat E, Kutner A, Opolski A
Anticancer Drugs
. 2007 Mar;
18(4):447-57.
PMID: 17351397
Analogs of 1,25-dihydroxyvitamin D3 with a reversed configuration at C-1 or C-24 and E or Z geometry of the double bond at C-22 in the side chain or at C-5...
20.
Chodynski M, Wietrzyk J, Marcinkowska E, Opolski A, Szelejewski W, Kutner A
Steroids
. 2002 Jul;
67(9):789-98.
PMID: 12123791
A series of analogs of 1,25-dihydroxyergocalciferol (1-4) was synthesized and screened for their antiproliferative activity in vitro. The structure of new analogs was designed based on biological activity of the...