Michael Zavortink
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Explore the profile of Michael Zavortink including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
287
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Recent Articles
1.
Lodge W, Zavortink M, Golenkina S, Froldi F, Dark C, Cheung S, et al.
Dev Cell
. 2021 Sep;
56(18):2664-2680.e6.
PMID: 34473940
Cachexia, the wasting syndrome commonly observed in advanced cancer patients, accounts for up to one-third of cancer-related mortalities. We have established a Drosophila larval model of organ wasting whereby epithelial...
2.
Glial Hedgehog signalling and lipid metabolism regulate neural stem cell proliferation in Drosophila
Dong Q, Zavortink M, Froldi F, Golenkina S, Lam T, Cheng L
EMBO Rep
. 2021 Mar;
22(5):e52130.
PMID: 33751817
The final size and function of the adult central nervous system (CNS) are determined by neuronal lineages generated by neural stem cells (NSCs) in the developing brain. In Drosophila, NSCs...
3.
Zavortink M, Rutt L, Dzitoyeva S, Henriksen J, Barrington C, Bilodeau D, et al.
Elife
. 2020 Jun;
9.
PMID: 32573431
The maternal-to-zygotic transition (MZT) is a conserved step in animal development, where control is passed from the maternal to the zygotic genome. Although the MZT is typically considered from its...
4.
Yao C, Wang C, Li Y, Zavortink M, Archambault V, Girton J, et al.
PLoS One
. 2018 Nov;
13(11):e0208022.
PMID: 30485354
In Drosophila it has recently been demonstrated that a spindle matrix in the form of a membrane-less macromolecular assembly embeds the microtubule-based spindle apparatus. In addition, two of its constituents,...
5.
Li Y, Wang C, Cai W, Sengupta S, Zavortink M, Deng H, et al.
Development
. 2017 Aug;
144(18):3232-3240.
PMID: 28807902
A model has been proposed in which JIL-1 kinase-mediated H3S10 and H2Av phosphorylation is required for transcriptional elongation and heat shock-induced chromatin decondensation. However, here we show that although H3S10...
6.
Sengupta S, Rath U, Yao C, Zavortink M, Wang C, Girton J, et al.
PLoS One
. 2016 Nov;
11(11):e0166829.
PMID: 27861562
In this study we provide evidence that the spindle matrix protein Skeletor in Drosophila interacts with the human ASCIZ (also known as ATMIN and ZNF822) ortholog, Digitor/dASCIZ. This interaction was...
7.
Gan W, Zavortink M, Ludick C, Templin R, Webb R, Webb R, et al.
J Cell Sci
. 2016 Feb;
130(1):143-151.
PMID: 26919978
The structural organisation of pancreatic β-cells in the islets of Langerhans is relatively unknown. Here, using three-dimensional (3D) two-photon, 3D confocal and 3D block-face serial electron microscopy, we demonstrate a...
8.
Low J, Zavortink M, Mitchell J, Gan W, Do O, Schwiening C, et al.
Diabetologia
. 2014 May;
57(8):1655-63.
PMID: 24795086
Aims/hypothesis: We set out to test the hypothesis that insulin secretion from beta cells is targeted towards the vasculature. Methods: The spatial location of granule fusion was identified by live-cell...
9.
Low J, Mitchell J, Do O, Bax J, Rawlings A, Zavortink M, et al.
Diabetologia
. 2013 Sep;
56(12):2629-37.
PMID: 23995471
Aims/hypothesis: In dispersed single beta cells the response of each cell to glucose is heterogeneous. In contrast, within an islet, cell-to-cell communication leads to glucose inducing a more homogeneous response....
10.
Chircop M, Sarcevic B, Larsen M, Malladi C, Chau N, Zavortink M, et al.
Biochim Biophys Acta
. 2011 Jan;
1813(10):1689-99.
PMID: 21195118
Calcineurin is a phosphatase that is activated at the last known stage of mitosis, abscission. Among its many substrates, it dephosphorylates dynamin II during cytokinesis at the midbody of dividing...