Michael Z Ludwig
Overview
Explore the profile of Michael Z Ludwig including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
490
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0
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Recent Articles
1.
Wu C, Lachance J, Ludwig M, Rebay I
PLoS Genet
. 2020 Nov;
16(11):e1009216.
PMID: 33253156
Spatiotemporally precise and robust cell fate transitions, which depend on specific signaling cues, are fundamental to the development of appropriately patterned tissues. The fidelity and precision with which photoreceptor fates...
2.
Su T, Ludwig M, Xu J, Fehon R
Dev Cell
. 2017 Mar;
40(5):478-490.e3.
PMID: 28292426
The Hippo pathway is emerging as a key evolutionarily conserved signaling mechanism that controls organ size. Three membrane-associated proteins, Kibra, Merlin, and Expanded, regulate pathway activity, but the precise molecular...
3.
Jiang P, Ludwig M, Kreitman M, Reinitz J
Dev Biol
. 2015 Jul;
405(1):173-81.
PMID: 26129990
The evolution of canalized traits is a central question in evolutionary biology. Natural variation in highly conserved traits can provide clues about their evolutionary potential. Here we investigate natural variation...
4.
Palsson A, Wesolowska N, Reynisdottir S, Ludwig M, Kreitman M
PLoS One
. 2014 May;
9(5):e91924.
PMID: 24786295
Changes in regulatory DNA contribute to phenotypic differences within and between taxa. Comparative studies show that many transcription factor binding sites (TFBS) are conserved between species whereas functional studies reveal...
5.
He B, Ludwig M, Dickerson D, Barse L, Arun B, Vilhjalmsson B, et al.
Genetics
. 2013 Nov;
196(2):557-67.
PMID: 24281155
The identification and validation of gene-gene interactions is a major challenge in human studies. Here, we explore an approach for studying epistasis in humans using a Drosophila melanogaster model of...
6.
Park S, Ludwig M, Tamarina N, He B, Carl S, Dickerson D, et al.
Genetics
. 2013 Nov;
196(2):539-55.
PMID: 24281154
Drosophila melanogaster has been widely used as a model of human Mendelian disease, but its value in modeling complex disease has received little attention. Fly models of complex disease would...
7.
Kim A, Martinez C, Ionides J, Ramos A, Ludwig M, Ogawa N, et al.
PLoS Genet
. 2013 Mar;
9(2):e1003243.
PMID: 23468638
Rearrangements of about 2.5 kilobases of regulatory DNA located 5' of the transcription start site of the Drosophila even-skipped locus generate large-scale changes in the expression of even-skipped stripes 2,...
8.
Manu , Ludwig M, Kreitman M
Genetics
. 2013 Feb;
194(1):163-73.
PMID: 23410834
The deleterious effects of different X-chromosome dosage in males and females are buffered by a process called dosage compensation, which in Drosophila is achieved through a doubling of X-linked transcription...
9.
Ludwig M, Manu , Kittler R, White K, Kreitman M
PLoS Genet
. 2011 Nov;
7(11):e1002364.
PMID: 22102826
The regulatory logic of time- and tissue-specific gene expression has mostly been dissected in the context of the smallest DNA fragments that, when isolated, recapitulate native expression in reporter assays....
10.
Lott S, Ludwig M, Kreitman M
Evolution
. 2010 Dec;
65(5):1388-99.
PMID: 21121913
Pattern formation in Drosophila is a widely studied example of a robust developmental system. Such robust systems pose a challenge to adaptive evolution, as they mask variation that selection may...