Michael Z Leonard
Overview
Explore the profile of Michael Z Leonard including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
171
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Recent Articles
1.
Myers J, Park W, Eddie A, Shinde A, Prasad P, Murphy A, et al.
bioRxiv
. 2024 Nov;
PMID: 39553975
Objective: Obesity is a major health concern, largely because it contributes to type 2 diabetes mellitus (T2DM), cardiovascular disease, and various malignancies. Increase in circulating amino acids and lipids, in...
2.
Leonard M, Miczek K, Covington 3rd H
Psychopharmacology (Berl)
. 2024 Nov;
242(3):593-615.
PMID: 39511030
Rationale: Anticipation is a critical antecedent to drug use, in which the prospect of imminent drug availability can potently motivate instrumental actions directed to procure it. Models that capture the...
3.
Thibeault K, Leonard M, Kondev V, Emerson S, Bethi R, Lopez A, et al.
Biol Psychiatry
. 2024 Jun;
97(6):590-601.
PMID: 38901723
Background: Substance use disorder is characterized by long-lasting changes in reward-related brain regions, such as the nucleus accumbens. Previous work has shown that cocaine exposure induces plasticity in broad, genetically...
4.
Zachry J, Kutlu M, Yoon H, Leonard M, Chevee M, Patel D, et al.
Neuron
. 2023 Dec;
112(5):835-849.e7.
PMID: 38134921
At the core of value-based learning is the nucleus accumbens (NAc). D1- and D2-receptor-containing medium spiny neurons (MSNs) in the NAc core are hypothesized to have opposing valence-based roles in...
5.
Raghav J, Kumar H, Ji L, Vemuri K, Makriyannis A, Suh J, et al.
Psychopharmacology (Berl)
. 2023 Nov;
241(3):427-443.
PMID: 38001264
Rationale: Alcohol use disorder (AUD) is a debilitating physiological and psychiatric disorder which affects individuals globally. The current pharmacological interventions to treat AUD are limited, and hence there is an...
6.
Chevee M, Kim C, Crow N, Follman E, Leonard M, Calipari E
eNeuro
. 2023 Sep;
10(9).
PMID: 37696663
Behavioral strategies are often classified based on whether reinforcer value controls reinforcement. Value-sensitive behaviors, in which animals update their actions when reinforcer value is changed, are classified as goal-directed; conversely,...
7.
Meckel K, Simpson S, Godino A, Peck E, Sens J, Leonard M, et al.
Neuropsychopharmacology
. 2023 Aug;
49(2):386-395.
PMID: 37528220
Cocaine use disorder represents a public health crisis with no FDA-approved medications for its treatment. A growing body of research has detailed the important connections between the brain and the...
8.
Follman E, Chevee M, Kim C, Johnson A, Tat J, Leonard M, et al.
Psychopharmacology (Berl)
. 2022 Dec;
240(1):213-225.
PMID: 36572717
Rationale: During operant conditioning, animals associate actions with outcomes. However, patterns and rates of operant responding change over learning, which makes it difficult to distinguish changes in learning from general...
9.
Miczek K, Akdilek N, Ferreira V, Kenneally E, Leonard M, Covington 3rd H
Psychopharmacology (Berl)
. 2022 Aug;
239(10):3287-3296.
PMID: 35974246
Rationale: The attraction to alcohol can be greatly increased when it is consumed in a social context. While pro-social interactions can potentiate voluntary alcohol drinking under some conditions, aversive social...
10.
Miczek K, Akdilek N, Ferreira V, Leonard M, Marinelli L, Covington 3rd H
Psychopharmacology (Berl)
. 2022 Aug;
239(10):3249-3261.
PMID: 35951078
Rationale: Alcohol consumption is a common antecedent of aggressive behavior. The effects of alcohol on the decision to engage in aggression in preference over pro-social interaction are hypothesized to arise...