Michael W Epperly
Overview
Explore the profile of Michael W Epperly including associated specialties, affiliations and a list of published articles.
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148
Citations
3213
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Recent Articles
1.
Alexander L, Khalid S, Gallego-Lopez G, Astmann T, Oh J, Heggen M, et al.
Appl Environ Microbiol
. 2024 Oct;
90(11):e0031224.
PMID: 39480094
Bacterial biotherapeutic delivery vehicles have the potential to treat a variety of diseases. This approach obviates the need to purify the recombinant effector molecule, allows delivery of therapeutics via oral...
2.
Fisher R, Epperly M, Rigatti L, Shields D, Greenberger J, Green A, et al.
In Vivo
. 2024 Oct;
38(6):2582-2590.
PMID: 39477388
Background/aim: Radiation oncologists are reluctant to treat cancer in Fanconi Anemia (FA) patients due to their lack of homologous recombination repair of DNA strand breaks in normal tissues. To determine...
3.
Wu Y, Christodoulou A, Beumer J, Rigatti L, Fisher R, Ross M, et al.
Radiat Res
. 2024 Jul;
202(3):565-579.
PMID: 39074819
Victims of a radiation terrorist event will include pregnant women and unborn fetuses. Mitochondrial dysfunction and oxidative stress are key pathogenic factors of fetal radiation injury. The goal of this...
4.
Greenberger J, Hou W, Shields D, Fisher R, Epperly M, Sarkaria I, et al.
In Vivo
. 2024 Jun;
38(4):1546-1556.
PMID: 38936937
Background/aim: There is concern that people who had COVID-19 will develop pulmonary fibrosis. Using mouse models, we compared pulmonary inflammation following injection of the spike protein of SARS-CoV-2 (COVID-19) to...
5.
Adeghate J, Epperly M, Davoli K, Lathrop K, Wipf P, Hou W, et al.
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928220
We hypothesize that the injection of JP4-039, a mitochondria-targeted nitroxide, prior to irradiation of the mouse retina may decrease apoptosis and reduce neutrophil and macrophage migration into the retina. In...
6.
Wu Y, Christodoulou A, Beumer J, Rigatti L, Fisher R, Ross M, et al.
bioRxiv
. 2024 Feb;
PMID: 38405696
One Sentence Summary: Mitochondrial-targeted gramicidin S (GS)-nitroxide JP4-039 is safe and effective radiation mitigator for mid-gestational fetal irradiation injury.
7.
Hamade D, Epperly M, Fisher R, Hou W, Shields D, van Pijkeren J, et al.
Cancers (Basel)
. 2024 Feb;
16(3).
PMID: 38339228
Despite recent advances in cancer therapy, ovarian cancer remains the most lethal gynecological cancer worldwide, making it crucial and of the utmost importance to establish novel therapeutic strategies. Adjuvant radiotherapy...
8.
Malekzadeh H, Surucu Y, Chinnapaka S, Yang K, Arellano J, Samadi Y, et al.
Stem Cell Res Ther
. 2024 Jan;
15(1):13.
PMID: 38185658
Background: Radiation therapy often leads to late radiation-induced skin fibrosis (RISF), causing movement impairment and discomfort. We conducted a comprehensive study to assess the effectiveness of metformin and adipose-derived stem...
9.
Epperly M, Mukherjee A, Fisher R, Shields D, Hou W, Wang H, et al.
In Vivo
. 2023 Oct;
37(6):2421-2432.
PMID: 37905617
Background/aim: Patients with radiation sensitive Fanconi anemia (FA) are presenting with cancers of the oral cavity, oropharynx, and other anatomic locations. Materials And Methods: Animal models for cancer in FA...
10.
Chinnapaka S, Yang K, Surucu Y, Bengur F, Arellano J, Tirmizi Z, et al.
iScience
. 2023 Sep;
26(9):107660.
PMID: 37705953
Radiation therapy can lead to late radiation-induced skin fibrosis (RISF), causing movement restriction, pain, and organ dysfunction. This study evaluated adipose-derived extracellular matrix (Ad-ECM) as a mitigator of RISF. Female...