Michael W Dougherty
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Explore the profile of Michael W Dougherty including associated specialties, affiliations and a list of published articles.
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10
Citations
286
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Recent Articles
1.
Dougherty M, Hoffmann R, Hernandez M, Airan Y, Gharaibeh R, Herzon S, et al.
mSphere
. 2025 Feb;
:e0069224.
PMID: 39918307
Importance: Colibactin has been implicated as a causative agent of colorectal cancer. However, colibactin-producing bacteria are also present in many healthy individuals, leading to the hypothesis that some aspects of...
2.
Dantzler M, Miller T, Dougherty M, Quevedo A
Reprod Sci
. 2024 Dec;
32(2):251-260.
PMID: 39707139
Alterations in the microbiome composition have been identified in common gynecologic pathologies such as endometriosis carving a new frontier in diagnosis and treatment. We aimed to examine the existing literature...
3.
Dougherty M, Russart N, Gaultney R, Gisi E, Cooper H, Kallis L, et al.
Ticks Tick Borne Dis
. 2024 Aug;
15(6):102385.
PMID: 39096783
Lyme disease has expanded into the Great Plains of the USA. To investigate local enzootic transmission, small mammals were trapped in two forested tracts in northeastern North Dakota during 2012...
4.
Dougherty M, Valdes-Mas R, Wernke K, Gharaibeh R, Yang Y, Brant J, et al.
Neoplasia
. 2023 Jul;
43:100918.
PMID: 37499275
Certain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as "pks" encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E. coli promote colorectal cancer (CRC) in preclinical...
5.
Dougherty M, Jobin C
Gut Microbes
. 2023 Mar;
15(1):2185028.
PMID: 36927206
The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible dietary or host-derived compounds and activate molecular...
6.
Vijayakurup V, Maeng K, Lee H, Meyer B, Burkett S, Nawab A, et al.
JCI Insight
. 2022 Sep;
7(19).
PMID: 36048542
Clinical studies of cancer patients have shown that overexpression or amplification of thymidylate synthase (TS) correlates with a worse clinical outcome. We previously showed that elevated TS exhibits properties of...
7.
Fu Z, Dean J, Xiong L, Dougherty M, Oliff K, Chen Z, et al.
Nat Commun
. 2021 Jul;
12(1):4462.
PMID: 34294718
RORγt lymphocytes, including interleukin 17 (IL-17)-producing gamma delta T (γδT17) cells, T helper 17 (Th17) cells, and group 3 innate lymphoid cells (ILC3s), are important immune regulators. Compared to Th17...
8.
Dougherty M, Jobin C
Toxins (Basel)
. 2021 Jun;
13(5).
PMID: 34065799
Colibactin is a secondary metabolite encoded by the gene island identified in several Enterobacteriaceae, including some pathogenic () commonly enriched in mucosal tissue collected from patients with inflammatory bowel disease...
9.
Dougherty M, Kudin O, Muhlbauer M, Neu J, Gharaibeh R, Jobin C
BMC Microbiol
. 2020 Jul;
20(1):205.
PMID: 32652929
Background: The intestinal tract undergoes a period of cellular maturation during early life, primarily characterized by the organization of epithelial cells into specialized crypt and villus structures. These processes are...
10.
He Z, Gharaibeh R, Newsome R, Pope J, Dougherty M, Tomkovich S, et al.
Gut
. 2018 Nov;
68(2):289-300.
PMID: 30377189
Objective: produces a genotoxin, cytolethal distending toxin (CDT), which has DNAse activity and causes DNA double-strand breaks. Although infection has been shown to promote intestinal inflammation, the impact of this...