Michael Santosuosso
Overview
Explore the profile of Michael Santosuosso including associated specialties, affiliations and a list of published articles.
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21
Citations
1464
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Recent Articles
1.
Huang Y, Yuan J, Righi E, Kamoun W, Ancukiewicz M, Nezivar J, et al.
Proc Natl Acad Sci U S A
. 2012 Oct;
109(43):17561-6.
PMID: 23045683
The recent approval of a prostate cancer vaccine has renewed hope for anticancer immunotherapies. However, the immunosuppressive tumor microenvironment may limit the effectiveness of current immunotherapies. Antiangiogenic agents have the...
2.
Righi E, Kashiwagi S, Yuan J, Santosuosso M, Leblanc P, Ingraham R, et al.
Cancer Res
. 2011 Jul;
71(16):5522-5534.
PMID: 21742774
The chemokine CXCL12 and its receptor CXCR4 are expressed widely in human cancers, including ovarian cancer, in which they are associated with disease progression at the levels of tumor cell...
3.
Santosuosso M, Righi E, Hill E, Leblanc P, Kodish B, Mylvaganam H, et al.
PLoS One
. 2011 Apr;
6(4):e18465.
PMID: 21483689
Background: HIV-1 is a pathogen that T cell responses fail to control. HIV-1gp120 is the surface viral envelope glycoprotein that interacts with CD4 T cells and mediates entry. HIV-1gp120 has...
4.
Siddappa N, Watkins J, Wassermann K, Song R, Wang W, Kramer V, et al.
PLoS One
. 2010 Jul;
5(7):e11689.
PMID: 20657739
Background: HIV-1 clade C (HIV-C) predominates worldwide, and anti-HIV-C vaccines are urgently needed. Neutralizing antibody (nAb) responses are considered important but have proved difficult to elicit. Although some current immunogens...
5.
Chenine A, Siddappa N, Kramer V, Sciaranghella G, Rasmussen R, Lee S, et al.
J Infect Dis
. 2010 Mar;
201(8):1155-63.
PMID: 20214475
Background: Worldwide, approximately 90% of all human immunodeficiency virus (HIV) transmissions occur mucosally; almost all involve R5 strains. Risks of sexual HIV acquisition are highest for rectal, then vaginal, and...
6.
Santosuosso M, Righi E, Lindstrom V, Leblanc P, Poznansky M
J Infect Dis
. 2009 Aug;
200(7):1050-3.
PMID: 19698075
The envelope protein of human immunodeficiency virus type 1 (HIV-1)--glycoprotein 120 (gp120)--has been demonstrated to dysregulate T cell function in vitro. We obtained autopsy tissues from individuals with chronic HIV-1...
7.
Hovav A, Santosuosso M, Bivas-Benita M, Plair A, Cheng A, Elnekave M, et al.
J Virol
. 2009 Aug;
83(21):10941-50.
PMID: 19692474
In order to increase the immune breadth of human immunodeficiency virus (HIV) vaccines, strategies such as immunization with several HIV antigens or centralized immunogens have been examined. HIV-1 gp120 protein...
8.
Stevceva L, Yoon V, Carville A, Pacheco B, Santosuosso M, Korioth-Schmitz B, et al.
J Immunol
. 2008 Oct;
181(8):5510-21.
PMID: 18832708
Gp120 is a critical component of the envelope of HIV-1. Its role in viral entry is well described. In view of its position on the viral envelope, gp120 is a...
9.
McCormick S, Santosuosso M, Small C, Shaler C, Zhang X, Jeyanathan M, et al.
J Immunol
. 2008 Aug;
181(4):2356-67.
PMID: 18684925
In vitro manipulated dendritic cells (DC) have increasingly been used as a promising vaccine formulation against cancer and infectious disease. However, improved understanding of the immune mechanisms is needed for...
10.
Small C, McCormick S, Gill N, Kugathasan K, Santosuosso M, Donaldson N, et al.
J Immunol
. 2008 Apr;
180(8):5558-68.
PMID: 18390740
Staphylococcus aureus remains a common cause of nosocomial bacterial infections and are often antibiotic resistant. The role of NK cells and IL-15 and their relationship in host defense against extracellular...