Michael S Middleton
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Explore the profile of Michael S Middleton including associated specialties, affiliations and a list of published articles.
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75
Citations
3581
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Recent Articles
1.
Zifan A, Zhao K, Lee M, Peng Z, Roney L, Pai S, et al.
Diagnostics (Basel)
. 2025 Jan;
15(2).
PMID: 39857001
Liver ultrasound segmentation is challenging due to low image quality and variability. While deep learning (DL) models have been widely applied for medical segmentation, generic pre-configured models may not meet...
2.
Pierce T, Ozturk A, Sherlock S, Moura Cunha G, Wang X, Li Q, et al.
Radiology
. 2024 Sep;
312(3):e233094.
PMID: 39254458
Background US shear-wave elastography (SWE) and vibration-controlled transient elastography (VCTE) enable assessment of liver stiffness, an indicator of fibrosis severity. However, limited reproducibility data restrict their use in clinical trials....
3.
Fowler K, Venkatesh S, Obuchowski N, Middleton M, Chen J, Pepin K, et al.
Radiology
. 2023 Oct;
309(1):e231092.
PMID: 37815451
Background There is a need for reliable noninvasive methods for diagnosing and monitoring nonalcoholic fatty liver disease (NAFLD). Thus, the multidisciplinary Non-invasive Biomarkers of Metabolic Liver disease (NIMBLE) consortium was...
4.
Wang K, Moura Cunha G, Hasenstab K, Henderson W, Middleton M, Cole S, et al.
AJR Am J Roentgenol
. 2023 Jul;
221(5):620-631.
PMID: 37466189
The confounder-corrected chemical shift-encoded MRI (CSE-MRI) sequence used to determine proton density fat fraction (PDFF) for hepatic fat quantification is not widely available. As an alternative, hepatic fat can be...
5.
Malki G, Goyal N, Ugalde-Nicalo P, Chun L, Zhang J, Ding Z, et al.
Metab Syndr Relat Disord
. 2023 Apr;
21(4):222-230.
PMID: 37083405
Pediatric studies have shown associations between hepatic steatosis and total body fat, visceral fat, and lean mass. However, these associations have not been assessed simultaneously, leaving their relative importance unknown....
6.
Shen W, Middleton M, M Cunha G, Delgado T, Wolfson T, Gamst A, et al.
J Hepatol
. 2022 Nov;
78(2):238-246.
PMID: 36368598
Background & Aims: Non-alcoholic steatohepatitis (NASH) is prevalent in adults with obesity and can progress to cirrhosis. In a secondary analysis of prospectively acquired data from the multicenter, randomized, placebo-controlled...
7.
Nedrud M, Chaudhry M, Middleton M, Moylan C, Lerebours R, Luo S, et al.
Radiology
. 2022 Nov;
306(3):e220743.
PMID: 36318027
Background Several early-phase clinical trials for the treatment of nonalcoholic steatohepatitis (NASH) use liver fat content as measured with the MRI-derived proton density fat fraction (PDFF) for a primary outcome....
8.
M Cunha G, Delgado T, Middleton M, Liew S, Henderson W, Batakis D, et al.
AJR Am J Roentgenol
. 2022 Feb;
219(2):224-232.
PMID: 35107306
Histologic fibrosis stage is the most important prognostic factor in chronic liver disease. MR elastography (MRE) is the most accurate noninvasive method for detecting and staging liver fibrosis. Although accurate,...
9.
Tang A, Dzyubak B, Yin M, Schlein A, Henderson W, Hooker J, et al.
Eur Radiol
. 2021 Dec;
32(5):2937-2948.
PMID: 34928415
Objectives: To assess reproducibility and fibrosis classification accuracy of magnetic resonance elastography (MRE)-determined liver stiffness measured manually at two different centers, and by automated analysis software in adults with nonalcoholic...
10.
Qu Y, Middleton M, Loomba R, Glaser K, Chen J, Hooker J, et al.
Eur Radiol
. 2021 Apr;
31(11):8408-8419.
PMID: 33899143
Objectives: To investigate associations between histology and hepatic mechanical properties measured using multiparametric magnetic resonance elastography (MRE) in adults with known or suspected nonalcoholic fatty liver disease (NAFLD) without histologic...