Michael S Manak
Overview
Explore the profile of Michael S Manak including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
309
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0
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Recent Articles
1.
Varsanik J, Manak M, Whitfield M, Hogan B, Su W, Jiang C, et al.
Rev Urol
. 2021 Apr;
22(4):159-167.
PMID: 33927573
To the usefulness and applications of machine vision (MV) and machine learning (ML) techniques that have been used to develop a single cell-based phenotypic (live and fixed biomarkers) platform that...
2.
Manak M, Varsanik J, Hogan B, Whitfield M, Su W, Joshi N, et al.
Nat Biomed Eng
. 2019 Mar;
2(10):761-772.
PMID: 30854249
The risk stratification of prostate cancer and breast cancer tumours from patients relies on histopathology, selective genomic testing, or on other methods employing fixed formalin tissue samples. However, static biomarker...
3.
Albala D, Manak M, Varsanik J, Rashid H, Mouraviev V, Zappala S, et al.
Urology
. 2018 Oct;
124:198-206.
PMID: 30312670
Objective: To examine the ability of a novel live primary-cell phenotypic (LPCP) test to predict postsurgical adverse pathology (P-SAP) features and risk stratify patients based on SAP features in a...
4.
Chander A, Manak M, Varsanik J, Hogan B, Mouraviev V, Zappala S, et al.
Urology
. 2017 Apr;
105:91-100.
PMID: 28365358
Objective: To culture prostate cells from fresh biopsy core samples from radical prostatectomy (RP) tissue. Further, given the genetic heterogeneity of prostate cells, the ability to culture single cells from...
5.
Kops G, van der Voet M, Manak M, van Osch M, Naini S, Brear A, et al.
J Cell Sci
. 2015 Nov;
128(21):4025.
PMID: 26527203
No abstract available.
6.
Paul A, Manak M, Mayfield J, Reyes M, Gurley W, Ferl R
Astrobiology
. 2011 Oct;
11(8):743-58.
PMID: 21970703
Our primary objective was to evaluate gene expression changes in Arabidopsis thaliana in response to parabolic flight as part of a comprehensive approach to the molecular biology of spaceflight-related adaptations....
7.
Hagan R, Manak M, Buch H, Meier M, Meraldi P, Shah J, et al.
Mol Biol Cell
. 2011 Oct;
22(22):4236-46.
PMID: 21965286
The spindle assembly checkpoint links the onset of anaphase to completion of chromosome-microtubule attachment and is mediated by the binding of Mad and Bub proteins to kinetochores of unattached or...
8.
Kops G, van der Voet M, van der Voet M, Manak M, van Osch M, Naini S, et al.
J Cell Sci
. 2010 Apr;
123(Pt 10):1623-33.
PMID: 20392738
Error-free chromosome segregation depends on timely activation of the multi-subunit E3 ubiquitin ligase APC/C. Activation of the APC/C initiates chromosome segregation and mitotic exit by targeting critical cell-cycle regulators for...
9.
Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak M, Kwon M, et al.
Nat Chem Biol
. 2010 Apr;
6(5):359-68.
PMID: 20383151
Mps1, a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and for the maintenance of chromosomal stability. As Mps1 function has been implicated in numerous...
10.
Manak M, Ferl R
Biochemistry
. 2007 Jan;
46(4):1055-63.
PMID: 17240989
Oscillations in cellular divalent cation concentrations are key events that can trigger signal transduction cascades. Common cellular divalent cations, such as calcium and magnesium, interact with 14-3-3 proteins. The metal...