Michael Polydefkis
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Explore the profile of Michael Polydefkis including associated specialties, affiliations and a list of published articles.
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2784
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Recent Articles
1.
Adams D, Wixner J, Polydefkis M, Berk J, Conceicao I, Dispenzieri A, et al.
JAMA Neurol
. 2025 Jan;
82(3):228-236.
PMID: 39804640
Importance: There is a lack of long-term efficacy and safety data on hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) and on RNA interference (RNAi) therapeutics in general. This study presents the...
2.
Wixner J, Berk J, Adams D, Polydefkis M, Conceicao I, Attarian S, et al.
Amyloid
. 2024 Nov;
32(1):29-38.
PMID: 39552152
Background: The NEURO-TTRansform trial showed that after 66 weeks of treatment, eplontersen significantly reduced neuropathic impairment and improved quality of life (QoL) in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy...
3.
Morrison A, Hoke M, Thomas S, Chaudhry V, Polydefkis M, Hoke A
J Peripher Nerv Syst
. 2024 Nov;
29(4):393-399.
PMID: 39506207
Background And Aims: Peripheral neuropathy (PN) is a common neurological condition in elderly adults. Vitamin D deficiency has been associated with diabetic and chemotherapy-induced neuropathy, but its role in idiopathic...
4.
Lane M, Polydefkis M
Neurol Ther
. 2024 Sep;
13(6):1527-1533.
PMID: 39240295
This article has been co-authored by a patient living with hereditary transthyretin (ATTRv) amyloidosis and a neurologist. This rare, progressive disease is associated with impairment of multiple organ systems, including...
5.
Shankar B, Yanek L, Jefferson A, Jani V, Brown E, Tsottles D, et al.
JACC CardioOncol
. 2024 Jul;
6(3):454-463.
PMID: 38983379
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is associated with significant mortality. The Val122Ile variant, highly prevalent in Black patients, portends poorer survival compared with other ATTR-CM subtypes. Although Val122Ile is biologically...
6.
Anderson S, Cavaletti G, Hood L, Polydefkis M, Herrmann D, Rance G, et al.
Pharmacol Res Perspect
. 2024 Jul;
12(4):e1204.
PMID: 38969959
Reversible axonal swelling and brainstem auditory evoked potential (BAEP) changes were observed in standard chronic (9-month) toxicology studies in dogs treated with ritlecitinib, an oral Janus kinase 3/tyrosine kinase expressed...
7.
Pasricha P, McKnight M, Villatoro L, Barahona G, Brinker J, Hui K, et al.
Am J Gastroenterol
. 2024 Jun;
119(11):2298-2306.
PMID: 38912927
Introduction: We examined autoimmunity markers (AIM) and autonomic dysfunction in patients with chronic neurogastroenterological symptoms and their relationship to joint hypermobility/hypermobility spectrum disorder (JH/HSD). Methods: AIM positivity was defined as...
8.
Berends M, Nienhuis H, Adams D, Karam C, Luigetti M, Polydefkis M, et al.
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612579
Peripheral and autonomic neuropathy are common disease manifestations in systemic amyloidosis. The neurofilament light chain (NfL), a neuron-specific biomarker, is released into the blood and cerebrospinal fluid after neuronal damage....
9.
Gami A, Woller J, Scheel P, Ali S, Huff C, Steenbergen Jr C, et al.
JACC Case Rep
. 2024 Mar;
29(7):102285.
PMID: 38465284
Although most patients with cardiac amyloidosis are diagnosed with either light chain (AL) or transthyretin (ATTR) disease, coexisting amyloid subtypes can occur. We present three cases of coexisting AL and...
10.
Karam C, Mauermann M, Gonzalez-Duarte A, Kaku M, Ajroud-Driss S, Brannagan 3rd T, et al.
Muscle Nerve
. 2024 Jan;
69(3):273-287.
PMID: 38174864
Hereditary transthyretin (ATTRv; v for variant) amyloidosis is a rare, multisystem, progressive, and fatal disease in which polyneuropathy is a cardinal manifestation. Due to a lack of United States (US)-specific...