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Michael P Pender

Explore the profile of Michael P Pender including associated specialties, affiliations and a list of published articles. Areas
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Articles 66
Citations 1455
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Recent Articles
1.
Ioannides Z, Csurhes P, Swayne A, Foubert P, Aftab B, Pender M
Mult Scler J Exp Transl Clin . 2021 Jun; 7(2):20552173211019772. PMID: 34158970
Background: Soluble triggering receptor expressed on myeloid cells-2 (sTREM-2) is a marker of macrophage and microglial activation and is increased in the cerebrospinal fluid (CSF) in multiple sclerosis (MS). Objective:...
2.
Ioannides Z, Csurhes P, Douglas N, Mackenroth G, Swayne A, Thompson K, et al.
Front Neurol . 2021 Apr; 12:652811. PMID: 33790852
Increasing evidence indicates a role for Epstein-Barr virus (EBV) in the pathogenesis of multiple sclerosis (MS). EBV-infected autoreactive B cells might accumulate in the central nervous system because of defective...
3.
Bar-Or A, Pender M, Khanna R, Steinman L, Hartung H, Maniar T, et al.
Trends Mol Med . 2021 Feb; 27(4):410-411. PMID: 33608230
No abstract available.
4.
Pender M, Csurhes P, Smith C, Douglas N, Neller M, Matthews K, et al.
JCI Insight . 2020 Oct; 5(20). PMID: 33055421
No abstract available.
5.
Greer J, Trifilieff E, Pender M
Front Immunol . 2020 Sep; 11:1891. PMID: 32973782
The most prominent pathological features of multiple sclerosis (MS) are demyelination and neurodegeneration. The exact pathogenesis of MS is unknown, but it is generally regarded as a T cell-mediated autoimmune...
6.
Yan J, McCombe P, Pender M, Greer J
J Clin Med . 2020 Aug; 9(8). PMID: 32781504
NF-κB signaling pathways are dysregulated in both the central nervous system (CNS) and peripheral blood cells in multiple sclerosis (MS), but the cause of this is unknown. We have recently...
7.
Pender M
Clin Transl Immunology . 2020 Apr; 9(4):e1116. PMID: 32257210
Bipolar disorder (BD) is a chronic disease characterised by episodes of major depression and episodes of mania or hypomania, with a worldwide prevalence of 2.4%. The cause of BD is...
8.
Bar-Or A, Pender M, Khanna R, Steinman L, Hartung H, Maniar T, et al.
Trends Mol Med . 2019 Dec; 26(3):296-310. PMID: 31862243
New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere of excitement in the MS community. B cells are now known to play a major role...
9.
Pender M, Csurhes P, Smith C, Douglas N, Neller M, Matthews K, et al.
JCI Insight . 2018 Nov; 3(22). PMID: 30429369
Background: Increasing evidence indicates a role for EBV in the pathogenesis of multiple sclerosis (MS). EBV-infected autoreactive B cells might accumulate in the CNS because of defective cytotoxic CD8+ T...
10.
Cloake N, Yan J, Aminian A, Pender M, Greer J
J Clin Med . 2018 Oct; 7(10). PMID: 30314286
is located on the X-chromosome and encodes myelin proteolipid protein (PLP), the most abundant protein in central nervous system myelin. Generally, point mutations in result in X-linked dysmyelinating disorders, such...