Michael P Czubryt
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Explore the profile of Michael P Czubryt including associated specialties, affiliations and a list of published articles.
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55
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1515
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Recent Articles
1.
Mogharehabed F, Czubryt M
Am J Physiol Cell Physiol
. 2023 Oct;
325(5):C1326-C1335.
PMID: 37781738
Muscular dystrophy exerts significant and dramatic impacts on affected patients, including progressive muscle wasting leading to lung and heart failure, and results in severely curtailed lifespan. Although the focus for...
2.
Nagalingam R, Chattopadhyaya S, Al-Hattab D, Cheung D, Schwartz L, Jana S, et al.
Eur Heart J
. 2022 Oct;
43(45):4739-4750.
PMID: 36200607
Aims: In response to pro-fibrotic signals, scleraxis regulates cardiac fibroblast activation in vitro via transcriptional control of key fibrosis genes such as collagen and fibronectin; however, its role in vivo...
3.
Al-Hattab D, Chattopadhyaya S, Czubryt M
Cells
. 2022 Jul;
11(15).
PMID: 35892569
Fibroblasts are stromal cells found in virtually every tissue and organ of the body. For many years, these cells were often considered to be secondary in functional importance to parenchymal...
4.
Rabinovich-Nikitin I, Blant A, Dhingra R, Kirshenbaum L, Czubryt M
Cells
. 2022 Jul;
11(14).
PMID: 35883637
Hypoxia exerts broad effects on cardiomyocyte function and viability, ranging from altered metabolism and mitochondrial physiology to apoptotic or necrotic cell death. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator...
5.
Chattopadhyaya S, Nagalingam R, Ledingham D, Moffatt T, Al-Hattab D, Narhan P, et al.
Cells
. 2022 May;
11(9).
PMID: 35563778
Fibrosis is an energy-intensive process requiring the activation of fibroblasts to myofibroblasts, resulting in the increased synthesis of extracellular matrix proteins. Little is known about the transcriptional control of energy...
6.
Aghanoori M, Agarwal P, Gauvin E, Nagalingam R, Bonomo R, Yathindranath V, et al.
Cell Mol Life Sci
. 2022 Mar;
79(4):193.
PMID: 35298717
Aberrant insulin-like growth factor 1 (IGF-1) signaling has been proposed as a contributing factor to the development of neurodegenerative disorders including diabetic neuropathy, and delivery of exogenous IGF-1 has been...
7.
Czubryt M, Hale T
Cell Signal
. 2021 Jun;
85:110066.
PMID: 34146658
Cardiac fibrosis is characteristic of the end stage in nearly all forms of heart disease. Accumulation of extracellular matrix in the myocardium leads to increased risk of arrhythmia and impaired...
8.
Koleini N, Nickel B, Nagalingam R, Landry N, Fandrich R, Cheung D, et al.
Cell Tissue Res
. 2021 May;
385(3):753-768.
PMID: 34057573
Fibroblast growth factor 2 (FGF2), produced as high (Hi-) and low (Lo-) molecular weight isoforms, is implicated in cardiac response to injury. The role of endogenous FGF2 isoforms during chronic...
9.
Garvin A, Khokhar B, Czubryt M, Hale T
Cell Signal
. 2020 Dec;
80:109903.
PMID: 33370581
Angiotensin II (Ang II) is a primary mediator of profibrotic signaling in the heart and more specifically, the cardiac fibroblast. Ang II-mediated cardiomyocyte hypertrophy in combination with cardiac fibroblast proliferation,...
10.
Alqudah M, Hale T, Czubryt M
Matrix Biol
. 2020 May;
91-92:92-108.
PMID: 32422329
Fibrosis is characterized by excessive deposition of extracellular matrix components such as collagen in tissues or organs. Fibrosis can develop in the heart, kidneys, liver, skin or any other body...