Michael Overholtzer
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Explore the profile of Michael Overholtzer including associated specialties, affiliations and a list of published articles.
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88
Citations
15196
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Recent Articles
11.
Hayashi A, Fan J, Chen R, Ho Y, Makohon-Moore A, Lecomte N, et al.
Nat Cancer
. 2022 Feb;
1(1):59-74.
PMID: 35118421
Pancreatic cancer expression profiles largely reflect a classical or basal-like phenotype. The extent to which these profiles vary within a patient is unknown. We integrated evolutionary analysis and expression profiling...
12.
Bandyopadhyay U, Todorova P, Pavlova N, Tada Y, Thompson C, Finley L, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(6).
PMID: 35105808
Cells acquire essential nutrients from the environment and utilize adaptive mechanisms to survive when nutrients are scarce. How nutrients are trafficked and compartmentalized within cells and whether they are stored...
13.
Overholtzer M
J Cell Biol
. 2021 Oct;
220(11).
PMID: 34643655
Cell death involves numerous mechanisms that can be cross-regulated through a complex signaling network. In this issue, Bozkurt et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010030) identify a new connection in the...
14.
Kim S, Zhang J, Jiang E, Overholtzer M
FASEB J
. 2021 Sep;
35(10):e21909.
PMID: 34547144
Metabolic stress contributes to the regulation of cell death in normal and diseased tissues. While different forms of cell death are known to be regulated by metabolic stress, how the...
15.
Chen R, Ram A, Albeck J, Overholtzer M
iScience
. 2021 Aug;
24(8):102902.
PMID: 34401679
Entosis is a cell death mechanism that is executed through neighbor cell ingestion and killing that occurs in cancer tissues and during development. Here, we identify JNK and p38 stress-activated...
16.
Katikaneni A, Jelcic M, Gerlach G, Ma Y, Overholtzer M, Niethammer P
Nat Cell Biol
. 2021 Apr;
23(5):566.
PMID: 33850303
No abstract available.
17.
Lee C, Overholtzer M
Autophagy
. 2021 Jan;
17(4):1034-1036.
PMID: 33499722
Lysosomes play an essential role in quality control mechanisms by functioning as the primary digestive system in mammalian cells. However, the quality control mechanisms governing healthy lysosomes are not fully...
18.
Lee C, Lamech L, Johns E, Overholtzer M
Dev Cell
. 2020 Sep;
55(3):289-297.e4.
PMID: 32916093
Lysosome function is essential for cellular homeostasis, but quality-control mechanisms that maintain healthy lysosomes remain poorly characterized. Here, we developed a method to measure lysosome turnover and use this to...
19.
Riegman M, Sagie L, Galed C, Levin T, Steinberg N, Dixon S, et al.
Nat Cell Biol
. 2020 Sep;
22(9):1042-1048.
PMID: 32868903
Ferroptosis is a regulated form of necrotic cell death that is caused by the accumulation of oxidized phospholipids, leading to membrane damage and cell lysis. Although other types of necrotic...
20.
Katikaneni A, Jelcic M, Gerlach G, Ma Y, Overholtzer M, Niethammer P
Nat Cell Biol
. 2020 Sep;
22(9):1049-1055.
PMID: 32868902
Rapid wound detection by distant leukocytes is essential for antimicrobial defence and post-infection survival. The reactive oxygen species hydrogen peroxide and the polyunsaturated fatty acid arachidonic acid are among the...