Michael Leith
Overview
Explore the profile of Michael Leith including associated specialties, affiliations and a list of published articles.
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2
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2
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Recent Articles
1.
Santos R, Lee S, Lofthouse R, Melis V, Robinson L, Leith M, et al.
FEBS J
. 2025 Feb;
PMID: 39960781
Tauopathies are a heterogeneous mixture of neurodegenerative disorders, including Alzheimer's disease and frontotemporal dementia (FTD), characterised by the accumulation of tau filaments in brain tissue. Tau protein aggregation is inhibited...
2.
Kondak C, Leith M, Baddeley T, Santos R, Harrington C, Wischik C, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37445987
Tau protein aggregations are important contributors to the etiology of Alzheimer's disease (AD). Hydromethylthionine (HMT) is a potent inhibitor of tau aggregation in vitro and in vivo and is being...
3.
Santos R, Melis V, Goatman E, Leith M, Baddeley T, Storey J, et al.
Biomedicines
. 2022 Apr;
10(4).
PMID: 35453617
The tau protein aggregation inhibitor hydromethylthionine mesylate (HMTM) was shown recently to have concentration-dependent pharmacological activity in delaying cognitive decline and brain atrophy in phase 3 Alzheimer's disease (AD) clinical...