Michael Laffan
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Explore the profile of Michael Laffan including associated specialties, affiliations and a list of published articles.
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37
Citations
1714
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Recent Articles
1.
Woollacott I, Chhabra A, Burke T, Brownrigg J, Richardson L, Ferri Grazzi E, et al.
BMC Health Serv Res
. 2024 Nov;
24(1):1437.
PMID: 39563410
Background: Few studies have evaluated direct medical or societal costs of haemophilia in the United Kingdom (UK), and how patient characteristics impact future costs is uncertain. Cost predictors were identified...
2.
Crossette-Thambiah C, Randi A, Laffan M
Haematologica
. 2024 Nov;
110(3):588-595.
PMID: 39506901
Bleeding in the gastrointestinal tract in patients with von Willebrand disease continues to pose a therapeutic challenge for clinicians. It is associated with significant morbidity and mortality and represents the...
3.
Curry N, Abu-Hanna J, Morrow G, Choudhury R, Laffan M
Haematologica
. 2024 Sep;
110(2):414-424.
PMID: 39234869
Trauma-induced coagulopathy describes a complex set of coagulation changes affecting severely injured patients. The thrombomodulin-protein C axis is believed to be central to the evolution of trauma-induced coagulopathy. Soluble thrombomodulin...
4.
Symington E, Rangarajan S, Lester W, Madan B, Pierce G, Raheja P, et al.
Haemophilia
. 2024 Feb;
30(2):320-330.
PMID: 38317480
Introduction: Valoctocogene roxaparvovec uses an adeno-associated virus serotype 5 (AAV5) vector to transfer a factor VIII (FVIII) coding sequence to individuals with severe haemophilia A, providing bleeding protection. Aim: To...
5.
Mitchell J, Khan D, Rana R, Kriek N, Unsworth A, Sage T, et al.
Platelets
. 2023 Oct;
34(1):2264940.
PMID: 37822056
Multiple myeloma (MM) and its precursor states, smoldering myeloma (SM) and monoclonal gammopathy of undetermined significance (MGUS) are associated with increased incidence of thrombosis, however the cause of this is...
6.
Simini G, Akor F, Szydlo R, Laffan M, Arachchillage D
Semin Thromb Hemost
. 2023 Aug;
50(2):298-302.
PMID: 37611622
No abstract available.
7.
Mahlangu J, Kaczmarek R, von Drygalski A, Shapiro S, Chou S, Ozelo M, et al.
N Engl J Med
. 2023 Feb;
388(8):694-705.
PMID: 36812433
Background: Valoctocogene roxaparvovec delivers a B-domain-deleted factor VIII coding sequence with an adeno-associated virus vector to prevent bleeding in persons with severe hemophilia A. The findings of a phase 3...
8.
Burke T, Rodriguez-Santana I, Chowdary P, Curtis R, Khair K, Laffan M, et al.
Haemophilia
. 2022 Dec;
29(2):608-618.
PMID: 36574369
Introduction: The "problem joint" (PJ) concept was developed to address patient-centric needs for a more holistic assessment of joint morbidity for people with haemophilia (PwH). Aim: To quantify the humanistic...
9.
Robbins A, Che Bakri N, Toke-Bjolgerud E, Edwards A, Vikraman A, Michalsky C, et al.
Br J Clin Pharmacol
. 2022 Nov;
89(4):1495-1501.
PMID: 36437688
COVID-19 causes significant thrombosis and coagulopathy, with elevated D-dimer a predictor of adverse outcome. The precise mechanism of this coagulopathy remains unclear; one hypothesis is that loss of angiotensin-converting enzyme...
10.
El Alayli A, Brignardello Petersen R, Husainat N, Kalot M, Aljabiri Y, Turkmani H, et al.
Haemophilia
. 2022 Mar;
28(3):373-387.
PMID: 35339117
Background: Von Willebrand Disease (VWD) is a common inherited bleeding disorder. Patients with VWD suffering from severe bleeding may benefit from the use of secondary long-term prophylaxis. Aim: Systematically summarize...