Michael L Simpson
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Explore the profile of Michael L Simpson including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Dar R, Shaffer S, Singh A, Razooky B, Simpson M, Raj A, et al.
PLoS One
. 2016 Jul;
11(7):e0158298.
PMID: 27467384
Recent analysis demonstrates that the HIV-1 Long Terminal Repeat (HIV LTR) promoter exhibits a range of possible transcriptional burst sizes and frequencies for any mean-expression level. However, these results have...
12.
Hansen R, Timm A, Timm C, Bible A, Morrell-Falvey J, Pelletier D, et al.
PLoS One
. 2016 Jul;
11(7):e0160135.
PMID: 27441627
[This corrects the article DOI: 10.1371/journal.pone.0155080.].
13.
Hansen R, Timm A, Timm C, Bible A, Morrell-Falvey J, Pelletier D, et al.
PLoS One
. 2016 May;
11(5):e0155080.
PMID: 27152511
The structure and function of microbial communities is deeply influenced by the physical and chemical architecture of the local microenvironment and the abundance of its community members. The complexity of...
14.
Dar R, Razooky B, Weinberger L, Cox C, Simpson M
PLoS One
. 2015 Oct;
10(10):e0140969.
PMID: 26488303
Protein noise measurements are increasingly used to elucidate biophysical parameters. Unfortunately noise analyses are often at odds with directly measured parameters. Here we show that these inconsistencies arise from two...
15.
Norred S, Caveney P, Retterer S, Boreyko J, Fowlkes J, Collier C, et al.
J Vis Exp
. 2015 Apr;
(97).
PMID: 25867144
Cell-free systems provide a flexible platform for probing specific networks of biological reactions isolated from the complex resource sharing (e.g., global gene expression, cell division) encountered within living cells. However,...
16.
Iyer S, Karig D, Norred S, Simpson M, Doktycz M
PLoS One
. 2013 Nov;
8(10):e78442.
PMID: 24194933
Engineered gene circuits offer an opportunity to harness biological systems for biotechnological and biomedical applications. However, reliance on native host promoters for the construction of circuit elements, such as logic...
17.
Karig D, Jung S, Srijanto B, Collier C, Simpson M
ACS Synth Biol
. 2013 May;
2(9):497-505.
PMID: 23688072
Cell-free systems offer a simplified and flexible context that enables important biological reactions while removing complicating factors such as fitness, division, and mutation that are associated with living cells. However,...
18.
Teng M, Bolovan-Fritts C, Dar R, Womack A, Simpson M, Shenk T, et al.
Cell
. 2012 Dec;
151(7):1569-80.
PMID: 23260143
Many signaling circuits face a fundamental tradeoff between accelerating their response speed while maintaining final levels below a cytotoxic threshold. Here, we describe a transcriptional circuitry that dynamically converts signaling...
19.
Dar R, Razooky B, Singh A, Trimeloni T, McCollum J, Cox C, et al.
Proc Natl Acad Sci U S A
. 2012 Oct;
109(43):17454-9.
PMID: 23064634
Gene expression occurs either as an episodic process, characterized by pulsatile bursts, or as a constitutive process, characterized by a Poisson-like accumulation of gene products. It is not clear which...
20.
Yu Z, McKnight T, Ericson M, Melechko A, Simpson M, Morrison 3rd B
Nanomedicine
. 2012 Mar;
8(4):419-23.
PMID: 22406183
From The Clinical Editor: The authors demonstrate the utility of a neural chip with lithographically defined arrays of vertically aligned carbon nanofiber electrodes. The new device can be used to...