Michael L Paffett
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Explore the profile of Michael L Paffett including associated specialties, affiliations and a list of published articles.
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24
Citations
465
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Recent Articles
1.
Saha B, Salemi M, Williams G, Oh S, Paffett M, Phinney B, et al.
Cell Rep
. 2022 May;
39(6):110797.
PMID: 35545034
The protein TRIM5α has multiple roles in antiretroviral defense, but the mechanisms underlying TRIM5α action are unclear. Here, we employ APEX2-based proteomics to identify TRIM5α-interacting partners. Our proteomics results connect...
2.
Noureddine A, Paffett M, Franco S, Chan A, Pallikkuth S, Lidke K, et al.
Pharmaceutics
. 2022 Jan;
14(1).
PMID: 35056951
This study examines intra- and intercellular trafficking of mesoporous silica nanoparticles along microtubular highways, with an emphasis on intercellular bridges connecting interphase and telophase cells. The study of nanoparticle trafficking...
3.
Franco S, Noureddine A, Guo J, Keth J, Paffett M, Brinker C, et al.
Cancers (Basel)
. 2020 Oct;
12(10).
PMID: 33050177
Macrophages line the walls of microvasculature, extending processes into the blood flow to capture foreign invaders, including nano-scale materials. Using mesoporous silica nanoparticles (MSNs) as a model nano-scale system, we...
4.
Norton C, Weise-Cross L, Ahmadian R, Yan S, Jernigan N, Paffett M, et al.
Am J Respir Cell Mol Biol
. 2020 Jan;
62(6):709-718.
PMID: 31945301
Chronic hypoxia (CH) augments depolarization-induced pulmonary vasoconstriction through superoxide-dependent, Rho kinase-mediated Ca sensitization. Nicotinamide adenine dinucleotide phosphate oxidase and EGFR (epidermal growth factor receptor) signaling contributes to this response. Caveolin-1...
5.
Zhang B, Paffett M, Naik J, Jernigan N, Walker B, Resta T
Curr Top Membr
. 2018 Oct;
82:53-91.
PMID: 30360783
Cholesterol is a key structural component and regulator of lipid raft signaling platforms critical for cell function. Such regulation may involve changes in the biophysical properties of lipid microdomains or...
6.
Oakley R, Campen M, Paffett M, Chen X, Wang Z, Parry T, et al.
BMC Med Genet
. 2018 Sep;
19(1):175.
PMID: 30241514
Background: We recently identified a role for the muscle-specific ubiquitin ligase MuRF1 in right-sided heart failure secondary to pulmonary hypertension induced by chronic hypoxia (CH). MuRF1-/- mice exposed to CH...
7.
Paffett M, Zychowski K, Sheppard L, Robertson S, Weaver J, Lucas S, et al.
Toxicol Sci
. 2015 May;
146(2):244-53.
PMID: 25962394
Ambient ozone (O3) levels are associated with cardiovascular morbidity and mortality, but the underlying pathophysiological mechanisms driving extrapulmonary toxicity remain unclear. This study examined the coronary vascular bed of rats...
8.
Campen M, Paffett M, Colombo E, Lucas S, Anderson T, Nysus M, et al.
PLoS One
. 2014 May;
9(5):e97084.
PMID: 24811453
Exposure to chronic hypoxia (CH) induces elevated pulmonary artery pressure/resistance, leading to an eventual maladaptive right ventricular hypertrophy (RVH). Muscle RING finger-1 (MuRF1) is a muscle-specific ubiquitin ligase that mediates...
9.
Colombo E, Davis J, Makvandi M, Aragon M, Lucas S, Paffett M, et al.
Cardiovasc Toxicol
. 2013 Aug;
13(4):364-9.
PMID: 23959951
Usage of nicotine-only formulations, such as transdermal patches, nicotine gum, or electronic nicotine delivery systems is increasing, as they are perceived as healthier alternatives to traditional cigarettes. Unfortunately, there is...
10.
Robertson S, Colombo E, Lucas S, Hall P, Febbraio M, Paffett M, et al.
Toxicol Sci
. 2013 May;
134(2):304-11.
PMID: 23650127
Inhaled pollutants induce the release of vasoactive factors into the systemic circulation, but little information is available regarding the nature of these factors or their receptors. The pattern recognition receptor...