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Michael Kovochich

Explore the profile of Michael Kovochich including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 30
Citations 1965
Followers 0
Related Specialties
Toxicology
Biotechnology
Pharmacology
Top 10 Co-Authors
Kenneth M Unice
Dennis J Paustenbach
Tian Xia
Andre E Nel
Brent L Finley
Monty Liong
Ernest S Fung
Jeffrey I Zink
Amy K Madl
Gary Eichenbaum
Published In
Regul Toxicol Pharmacol
ACS Nano
Crit Rev Toxicol
Sci Total Environ
Nanomedicine
Affiliations
Soon will be listed here.
Recent Articles
1.
A quantitative weight-of-evidence review of preclinical studies examining the potential developmental and reproductive toxicity of acetaminophen
Kougias D, Southall M, Scialli A, Atillasoy E, Ejaz S, Schaeffer T, et al.
Crit Rev Toxicol . 2025 Feb; :1-48. PMID: 39982149
We previously developed a quantitative weight-of-evidence (QWoE) framework using prespecified scoring criteria for preclinical acetaminophen data to characterize potential developmental neurotoxicity outcomes with considerations for biological relevance of the response...
2.
A quantitative weight-of-evidence review of preclinical studies examining the potential developmental neurotoxicity of acetaminophen
Kougias D, Atillasoy E, Southall M, Scialli A, Ejaz S, Chu C, et al.
Crit Rev Toxicol . 2025 Feb; :1-55. PMID: 39982125
Acetaminophen [paracetamol; -acetyl--aminophenol (APAP)] is an antipyretic/analgesic commonly used in the treatment of fever and mild to moderate pain, headache, myalgia, and dysmenorrhea. Recent literature has questioned the safety of...
3.
An integrated benefit-risk assessment of cobalt-containing alloys used in medical devices: Implications for regulatory requirements in the European Union
Eichenbaum G, Wilsey J, Fessel G, Qiu Q, Perkins L, Hasgall P, et al.
Regul Toxicol Pharmacol . 2021 Jul; 125:105004. PMID: 34256083
In 2017, the European Union (EU) Committee for Risk Assessment (RAC) recommended the classification of metallic cobalt (Co) as Category 1B with respect to its carcinogenic and reproductive hazard potential...
4.
A hazard evaluation of the reproductive/developmental toxicity of cobalt in medical devices
Monnot A, Kovochich M, Bandara S, Wilsey J, Christian W, Eichenbaum G, et al.
Regul Toxicol Pharmacol . 2021 Apr; 123:104932. PMID: 33872739
Cobalt (Co) is an essential element with human exposure occurring from the diet, supplement ingestion, occupational sources, and medical devices. The European Chemical Agency (ECHA) recently voted to classify Co...
5.
Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles
More S, Kovochich M, Lyons-Darden T, Taylor M, Schulte A, Madl A
Nanomaterials (Basel) . 2021 Apr; 11(3). PMID: 33807756
The exceptional physical and chemical properties of nickel nanomaterials have been exploited in a range of applications such as electrical conductors, batteries, and biomaterials. However, it has been suggested that...
6.
Carcinogenic hazard assessment of cobalt-containing alloys in medical devices: Review of in vivo studies
Kovochich M, Monnot A, Kougias D, More S, Wilsey J, Qiu Q, et al.
Regul Toxicol Pharmacol . 2021 Mar; 122:104910. PMID: 33662479
Cobalt (Co) alloys have been used for over seven decades in a wide range of medical devices, including, but not limited to, hip and knee implants, surgical tools, and vascular...
7.
A comprehensive weight of evidence assessment of published acetaminophen genotoxicity data: Implications for its carcinogenic hazard potential
Kirkland D, Kovochich M, More S, Murray F, Monnot A, Miller J, et al.
Regul Toxicol Pharmacol . 2021 Feb; 122:104892. PMID: 33592196
In 2019, the California Office of Environmental Health Hazard Assessment initiated a review of the carcinogenic hazard potential of acetaminophen, including an assessment of its genotoxicity. The objective of this...
8.
Chemical mapping of tire and road wear particles for single particle analysis
Kovochich M, Liong M, Parker J, Oh S, Lee J, Xi L, et al.
Sci Total Environ . 2020 Dec; 757:144085. PMID: 33333431
Tire and road wear particles (TRWP), which are comprised of polymer-containing tread with pavement encrustations, are generated from friction between the tire and the road. Similar to environmentally dispersed microplastic...
9.
Risk Assessment of Glyphosate Exposures from Pilot Study with Simulated Heavy Residential Consumer Application of Roundup using a Margin of Safety (MOS) Approach
Kougias D, Miller E, McEwen A, Reamer H, Kovochich M, Pierce J
Risk Anal . 2020 Nov; 41(9):1693-1715. PMID: 33245586
Due to the widespread application of glyphosate, a nonselective herbicide, to a variety of resistant food crops, the general population is exposed to glyphosate through dietary intake. Despite this, dietary...
10.
A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential
Murray F, Monnot A, Jacobson-Kram D, Cohen S, Hardisty J, Bandara S, et al.
Regul Toxicol Pharmacol . 2020 Oct; 118:104801. PMID: 33039518
In 2019 the California Office of Environmental Health Hazard Assessment (OEHHA) initiated a review of the carcinogenic hazard potential of acetaminophen, including an assessment of the long-term rodent carcinogenicity and...