Michael J Pena
Overview
Explore the profile of Michael J Pena including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
52
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0
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Recent Articles
1.
Ma L, Acuff N, Joseph I, Ptacin J, Caffaro C, San Jose K, et al.
Cancer Res Commun
. 2024 Sep;
4(10):2799-2814.
PMID: 39320047
Significance: SAR-444245 (SAR'245, pegenzileukin) is an extended half-life IL-2 that targets effector CD8+ T and NK cells, with little effect on regulatory T cells. We show that in the nonhuman...
2.
Ptacin J, Ma L, Caffaro C, Acuff N, Germar K, Severy P, et al.
Commun Med (Lond)
. 2024 Mar;
4(1):58.
PMID: 38532017
Background: Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK) properties. Recombinant human interleukin-2 (rhIL-2) has shown promise for treatment of autoimmune...
3.
Ptacin J, Caffaro C, Ma L, San Jose Gall K, Aerni H, Acuff N, et al.
Nat Commun
. 2021 Aug;
12(1):4785.
PMID: 34373459
The implementation of applied engineering principles to create synthetic biological systems promises to revolutionize medicine, but application of fundamentally redesigned organisms has thus far not impacted practical drug development. Here...