Michael J Greig
Overview
Explore the profile of Michael J Greig including associated specialties, affiliations and a list of published articles.
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11
Citations
251
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Recent Articles
1.
Greig M, Niessen S, Weinrich S, Feng J, Shi M, Johnson T
Int J Cell Biol
. 2015 Dec;
2015:798936.
PMID: 26689952
Rapid mutations of proteins that are targeted in cancer therapy often lead to drug resistance. Often, the mutation directly affects a drug's binding site, effectively blocking binding of the drug,...
2.
Cardoso R, Love R, Nilsson C, Bergqvist S, Nowlin D, Yan J, et al.
Protein Sci
. 2012 Oct;
21(12):1885-96.
PMID: 23033253
The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be...
3.
Dillon R, Nilsson C, Shi S, Lee N, Krastins B, Greig M
J Proteome Res
. 2011 Sep;
10(11):5084-94.
PMID: 21936566
In recent years, there have been notable advances with the development of anticancer drugs including those targeting protein tyrosine kinases such as the c-Met receptor, which has been implicated in...
4.
Zhang H, Yu X, Greig M, Gajiwala K, Wu J, Diehl W, et al.
Protein Sci
. 2010 Jan;
19(4):703-15.
PMID: 20095048
Mutations of the receptor tyrosine kinase KIT are linked to certain cancers such as gastrointestinal stromal tumors (GISTs). Biophysical, biochemical, and structural studies have provided insight into the molecular basis...
5.
Gajiwala K, Wu J, Christensen J, Deshmukh G, Diehl W, DiNitto J, et al.
Proc Natl Acad Sci U S A
. 2009 Jan;
106(5):1542-7.
PMID: 19164557
Most gastrointestinal stromal tumors (GISTs) exhibit aberrant activation of the receptor tyrosine kinase (RTK) KIT. The efficacy of the inhibitors imatinib mesylate and sunitinib malate in GIST patients has been...
6.
Dillon R, Greig M, Bhat B
Anal Chim Acta
. 2008 Sep;
627(1):99-104.
PMID: 18790132
Stearoyl-CoA desaturase 1 (SCD1) is an enzyme that catalyzes the rate-limiting step in de novo synthesis of monounsaturated fatty acids--mainly oleate and palmitoleate from stearoyl-CoA and palmitoyl-Co A, respectively. These...
7.
Emmett M, Kazazic S, Marshall A, Chen W, Shi S, Bolanos B, et al.
Anal Chem
. 2006 Sep;
78(19):7058-60.
PMID: 17007536
The single biggest problem with solution-phase H/D exchange as a mass spectrometric probe of surface exposure in a protein (or protein complex) is back-exchange of H for D after the...
8.
Shi S, Greig M, Solowiej J, Murray B
J Chromatogr B Analyt Technol Biomed Life Sci
. 2005 May;
825(2):176-85.
PMID: 15899596
Liquid chromatography-mass spectrometry (LC-MS) has been used extensively in determination of the molecular weights of proteins, as well as covalent protein-ligand complexes. We have successfully developed LC-MS method for protein...
9.
Greig M, Bolanos B, Quenzer T, Bylund J
Rapid Commun Mass Spectrom
. 2003 Dec;
17(24):2763-8.
PMID: 14673824
Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS) was coupled with atmospheric pressure photoionization (APPI) for the first time and used for the analysis of several corticosteroids.1 The analytes showed...
10.
Bolanos B, Ventura M, Greig M
J Comb Chem
. 2003 Jul;
5(4):451-5.
PMID: 12857113
The advantage of high-speed time-of-flight-mass spectrometry (TOF-MS) detection for ultrafast qualitative supercritical fluid chromatography/mass spectrometry (SFC/MS) applications allows the superior resolving power of SFC to be exploited in high-throughput analysis....