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Michael Holst

Explore the profile of Michael Holst including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
11.
Balasubramanian M, Kriegman D, Bowd C, Holst M, Weinreb R, Sample P, et al.
Invest Ophthalmol Vis Sci . 2012 Apr; 53(7):3615-28. PMID: 22491406
Purpose: To detect localized glaucomatous structural changes using proper orthogonal decomposition (POD) framework with false-positive control that minimizes confirmatory follow-ups, and to compare the results to topographic change analysis (TCA)....
12.
Holst M, McCammon J, Yu Z, Zhou Y, Zhu Y
Commun Comput Phys . 2011 Sep; 11(1):179-214. PMID: 21949541
We consider the design of an effective and reliable adaptive finite element method (AFEM) for the nonlinear Poisson-Boltzmann equation (PBE). We first examine the two-term regularization technique for the continuous...
13.
Yu Z, Yao G, Hoshijima M, Michailova A, Holst M
IEEE Trans Biomed Eng . 2011 Jun; 58(10):2947-51. PMID: 21632291
Spatial-temporal Ca(2+) dynamics due to Ca(2+) release, buffering, and reuptaking plays a central role in studying excitation-contraction (E-C) coupling in both normal and diseased cardiac myocytes. In this paper, we...
14.
Zhou Y, Holst M, McCammon J
J Math Anal Appl . 2009 May; 340(1):135-164. PMID: 19461946
In this paper we propose a nonlinear elasticity model of macromolecular conformational change (deformation) induced by electrostatic forces generated by an implicit solvation model. The Poisson-Boltzmann equation for the electrostatic...
15.
Lu S, Michailova A, Saucerman J, Cheng Y, Yu Z, Kaiser T, et al.
IEEE Eng Med Biol Mag . 2009 Apr; 28(2):46-57. PMID: 19349251
There is a growing body of experimental evidence suggesting that the Ca(2+) signaling in ventricular myocytes is characterized by a high gradient near the cell membrane and a more uniform...