Michael Graner
Overview
Explore the profile of Michael Graner including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
3205
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0
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Recent Articles
1.
Raphael I, Mujeeb A, Ampudia-Mesias E, Sever R, McClellan B, Frederico S, et al.
bioRxiv
. 2024 Sep;
PMID: 39314283
Statement Of Significance: We demonstrate mechanisms of the druggable glioma-derived CD200 checkpoint on tumor growth and immune suppression.
2.
Zhou W, Graner M, Beseler C, Domashevich T, Selva S, Webster G, et al.
Clin Immunol
. 2023 Oct;
256:109801.
PMID: 37816415
We recently reported that multiple sclerosis (MS) plasma contains IgG aggregates and induces complement-dependent neuronal cytotoxicity (Zhou et al., 2023). Using ELISA, we report herein that plasma IgG levels in...
3.
Zhou W, Graner M, Paucek P, Beseler C, Boisen M, Bubak A, et al.
Cell Death Dis
. 2023 Apr;
14(4):254.
PMID: 37031195
Grey matter pathology is central to the progression of multiple sclerosis (MS). We discovered that MS plasma immunoglobulin G (IgG) antibodies, mainly IgG1, form large aggregates (>100 nm) which are...
4.
Kennedy P, Graner M, Pointon T, Li X, Tanimoto K, Dennison K, et al.
J Neuroimmune Pharmacol
. 2021 May;
17(1-2):218-227.
PMID: 33942224
A hallmark of the inflammatory response in multiple sclerosis (MS) is the presence of intrathecal Immunoglobulin G (IgG) antibodies and oligoclonal bands (OCBs). The biological activity of IgGs is modulated...
5.
Yu X, Graner M, Kennedy P, Liu Y
Front Neurol
. 2020 Nov;
11:533388.
PMID: 33192968
The presence of persistent intrathecal oligoclonal immunoglobulin G (IgG) bands (OCBs) and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease pathology. Despite extensive investigations, the role of...
6.
Coughlan C, Bruce K, Burgy O, Boyd T, Michel C, Garcia-Perez J, et al.
Curr Protoc Cell Biol
. 2020 Jul;
88(1):e110.
PMID: 32633898
Exosomes are 50- to 150-nm-diameter extracellular vesicles secreted by all mammalian cells except mature red blood cells and contribute to diverse physiological and pathological functions within the body. Many methods...
7.
Graner M, Pointon T, Manton S, Green M, Dennison K, Davis M, et al.
PLoS One
. 2020 Feb;
15(2):e0228883.
PMID: 32084151
IgG oligoclonal bands (OCBs) are present in the cerebrospinal fluid (CSF) of more than 95% of patients with multiple sclerosis (MS), and are considered to be the immunological hallmark of...
8.
9.
Beseler C, Vollmer T, Graner M, Yu X
PLoS One
. 2017 Oct;
12(10):e0186842.
PMID: 29059249
Introduction: Intrathecal immunoglobulin G (IgG) and oligoclonal bands (OCBs) are the most consistent and characteristic features of Multiple Sclerosis (MS). OCBs in MS are considered products of clonally expanded B...
10.
Schlaepfer I, Nambiar D, Ramteke A, Kumar R, Dhar D, Agarwal C, et al.
Oncotarget
. 2015 Jun;
6(26):22836-56.
PMID: 26087400
Hypoxia is an independent prognostic indicator of poor outcome in several malignancies. However, precise mechanism through which hypoxia promotes disease aggressiveness is still unclear. Here, we report that under hypoxia...