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Michael Geralt

Explore the profile of Michael Geralt including associated specialties, affiliations and a list of published articles. Areas
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Articles 24
Citations 2918
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Recent Articles
1.
Serrano P, Hammond J, Geralt M, Wuthrich K
Biochemistry . 2018 Feb; 57(10):1563-1567. PMID: 29450990
Splicing factor RBM10 and its close homologues RBM5 and RBM6 govern the splicing of oncogenes such as Fas, NUMB, and Bcl-X. The molecular architecture of these proteins includes zinc fingers...
2.
Proudfoot A, Geralt M, Elsliger M, Wilson I, Wuthrich K, Serrano P
Structure . 2016 Jul; 24(8):1372-1379. PMID: 27396829
The Gastrulation Brain Homeobox 1 (Gbx1) gene encodes the Gbx1 homeodomain that targets TAATTA motifs in double-stranded DNA (dsDNA). Residues Glu17 and Arg52 in Gbx1 form a salt bridge, which...
3.
Serrano P, Dutta S, Proudfoot A, Mohanty B, Susac L, Martin B, et al.
FEBS J . 2016 May; 283(21):3870-3881. PMID: 27154589
For more than a decade, the Joint Center for Structural Genomics (JCSG; www.jcsg.org) worked toward increased three-dimensional structure coverage of the protein universe. This coordinated quest was one of the...
4.
Serrano P, Aubol B, Keshwani M, Forli S, Ma C, Dutta S, et al.
J Mol Biol . 2016 Apr; 428(11):2430-2445. PMID: 27091468
Multisite phosphorylation is required for the biological function of serine-arginine (SR) proteins, a family of essential regulators of mRNA splicing. These modifications are catalyzed by serine-arginine protein kinases (SRPKs) that...
5.
Stepanyuk G, Serrano P, Peralta E, Farr C, Axelrod H, Geralt M, et al.
Acta Crystallogr D Struct Biol . 2016 Apr; 72(Pt 4):497-511. PMID: 27050129
RNA-binding protein 39 (RBM39) is a splicing factor and a transcriptional co-activator of estrogen receptors and Jun/AP-1, and its function has been associated with malignant progression in a number of...
6.
Proudfoot A, Axelrod H, Geralt M, Fletterick R, Yumoto F, Deacon A, et al.
J Mol Biol . 2016 Feb; 428(6):1130-1141. PMID: 26829219
The Dlx5 homeodomain is a transcription factor related to the Drosophila distal-less gene that is associated with breast and lung cancer, lymphoma, Rett syndrome and osteoporosis in humans. Mutations in...
7.
Mohanty B, Geralt M, Wuthrich K, Serrano P
Protein Sci . 2016 Jan; 25(4):917-25. PMID: 26749007
The protein NP_344798.1 from Streptococcus pneumoniae TIGR4 exhibits a head and base-interacting neck domain architecture, as observed in class II nucleotide-adding enzymes. Although it has less than 20% overall sequence...
8.
Martin B, Serrano P, Geralt M, Wuthrich K
Structure . 2015 Dec; 24(1):158-164. PMID: 26712279
The OCtamer REpeat (OCRE) has been annotated as a 42-residue sequence motif with 12 tyrosine residues in the spliceosome trans-regulatory elements RBM5 and RBM10 (RBM [RNA-binding motif]), which are known...
9.
Dutta S, Serrano P, Geralt M, Axelrod H, Xu Q, Lesley S, et al.
Protein Sci . 2015 Jul; 24(10):1600-8. PMID: 26177955
Flavodoxins in combination with the flavin mononucleotide (FMN) cofactor play important roles for electron transport in prokaryotes. Here, novel insights into the FMN-binding mechanism to flavodoxins-4 were obtained from the...
10.
Mohanty B, Serrano P, Geralt M, Wuthrich K
J Biomol NMR . 2014 Nov; 61(1):83-7. PMID: 25430057
No abstract available.