Michael G B Blum
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Explore the profile of Michael G B Blum including associated specialties, affiliations and a list of published articles.
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46
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2389
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Recent Articles
1.
Alves I, Giemza J, Blum M, Bernhardsson C, Chatel S, Karakachoff M, et al.
Nat Commun
. 2024 Aug;
15(1):6710.
PMID: 39112481
The demographical history of France remains largely understudied despite its central role toward understanding modern population structure across Western Europe. Here, by exploring publicly available Europe-wide genotype datasets together with...
2.
Boidot R, Blum M, Wissler M, Gottin C, Ruzicka J, Chevrier S, et al.
Eur J Cancer
. 2024 Mar;
202:113978.
PMID: 38471290
Background: The PAOLA-1/ENGOT-ov25 trial showed that maintenance olaparib plus bevacizumab increases survival of advanced ovarian cancer patients with homologous recombination deficiency (HRD). However, decentralized solutions to test for HRD in...
3.
Momal R, Li H, Trichelair P, Blum M, Balazard F
Trials
. 2023 Jun;
24(1):380.
PMID: 37280655
Adjustment for prognostic covariates increases the statistical power of randomized trials. The factors influencing the increase of power are well-known for trials with continuous outcomes. Here, we study which factors...
4.
Loiseau N, Trichelair P, He M, Andreux M, Zaslavskiy M, Wainrib G, et al.
BMC Med Res Methodol
. 2022 Dec;
22(1):335.
PMID: 36577946
Background: An external control arm is a cohort of control patients that are collected from data external to a single-arm trial. To provide an unbiased estimation of efficacy, the clinical...
5.
Lassau N, Ammari S, Chouzenoux E, Gortais H, Herent P, Devilder M, et al.
Nat Commun
. 2021 Jan;
12(1):634.
PMID: 33504775
The SARS-COV-2 pandemic has put pressure on intensive care units, so that identifying predictors of disease severity is a priority. We collect 58 clinical and biological variables, and chest CT...
6.
Sjostrand A, Sjodin P, Hegay T, Nikolaeva A, Shayimkulov F, Blum M, et al.
Eur J Hum Genet
. 2020 Oct;
29(2):325-337.
PMID: 33005019
Taste is essential for the interaction of animals with their food and has co-evolved with diet. Humans have peopled a large range of environments and present a wide range of...
7.
Prive F, Luu K, Blum M, McGrath J, Vilhjalmsson B
Bioinformatics
. 2020 May;
36(16):4449-4457.
PMID: 32415959
Motivation: Principal component analysis (PCA) of genetic data is routinely used to infer ancestry and control for population structure in various genetic analyses. However, conducting PCA analyses can be complicated...
8.
Blum M, Valeri L, Francois O, Cadiou S, Siroux V, Lepeule J, et al.
Environ Health Perspect
. 2020 May;
128(5):55001.
PMID: 32379489
Background: Mediation analysis is used in epidemiology to identify pathways through which exposures influence health. The advent of high-throughput (omics) technologies gives opportunities to perform mediation analysis with a high-dimension...
9.
Prive F, Luu K, Vilhjalmsson B, Blum M
Mol Biol Evol
. 2020 Apr;
37(7):2153-2154.
PMID: 32343802
R package pcadapt is a user-friendly R package for performing genome scans for local adaptation. Here, we present version 4 of pcadapt which substantially improves computational efficiency while providing similar...
10.
Decamps C, Prive F, Bacher R, Jost D, Waguet A, Houseman E, et al.
BMC Bioinformatics
. 2020 Jan;
21(1):16.
PMID: 31931698
Background: Cell-type heterogeneity of tumors is a key factor in tumor progression and response to chemotherapy. Tumor cell-type heterogeneity, defined as the proportion of the various cell-types in a tumor,...