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Michael Fruhwald

Explore the profile of Michael Fruhwald including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 32
Citations 1072
Followers 0
Related Specialties
Oncology
Pediatrics
Hematology
Top 10 Co-Authors
Martin Hasselblatt
Markus Metzler
Marcel Kool
Stefan Rutkowski
Uwe Kordes
Reiner Siebert
Pascal D Johann
Angelika Eggert
Ewa Koscielniak
Norbert Graf
Published In
Pediatr Blood Cancer
Cancers (Basel)
Neuro Oncol
Nature
JAMA Netw Open
Affiliations
Soon will be listed here.
Recent Articles
1.
Irinotecan and temozolomide in combination with dasatinib and rapamycin versus irinotecan and temozolomide for patients with relapsed or refractory neuroblastoma (RIST-rNB-2011): a multicentre, open-label, randomised, controlled, phase 2 trial
Corbacioglu S, Lode H, Ellinger S, Zeman F, Suttorp M, Escherich G, et al.
Lancet Oncol . 2024 Jun; 25(7):922-932. PMID: 38936379
Background: Neuroblastoma is the most common extracranial solid tumour in children. Relapsed or refractory neuroblastoma is associated with a poor outcome. We assessed the combination of irinotecan-temozolomide and dasatinib-rapamycin (RIST)...
2.
Non-Syndromic and Syndromic Defects in Children with Extracranial Germ Cell Tumors: Data of 2610 Children Registered with the German MAKEI 96/MAHO 98 Registry Compared to the General Population
Schultewolter J, Rissmann A, von Schweinitz D, Fruhwald M, Blattmann C, Fischer L, et al.
Cancers (Basel) . 2024 Jun; 16(11). PMID: 38893276
GCTs are developmental tumors and are likely to reflect ontogenetic and teratogenetic determinants. The objective of this study was to identify syndromes with or without congenital anomalies and non-syndromic defects...
3.
Human-Level Differentiation of Medulloblastoma from Pilocytic Astrocytoma: A Real-World Multicenter Pilot Study
Wiestler B, Bison B, Behrens L, Tuchert S, Metz M, Griessmair M, et al.
Cancers (Basel) . 2024 Apr; 16(8). PMID: 38672556
Medulloblastoma and pilocytic astrocytoma are the two most common pediatric brain tumors with overlapping imaging features. In this proof-of-concept study, we investigated using a deep learning classifier trained on a...
4.
Approaches for bridging therapy prior to chimeric antigen receptor T cells for relapsed/refractory acute lymphoblastic B-lineage leukemia in children and young adults
Feuchtinger T, Bader P, Subklewe M, Breidenbach M, Willier S, Metzler M, et al.
Haematologica . 2024 Feb; 109(12):3892-3903. PMID: 38356450
The ongoing development of immunotherapies, including chimeric antigen receptor (CAR) T cells, has revolutionized cancer treatment. In pediatric relapsed/refractory B-lineage acute leukemia antiCD19-CAR induce impressive initial response rates, with event-free...
5.
NUT carcinoma in pediatric patients: Characteristics, therapeutic regimens, and outcomes of 11 cases registered with the German Registry for Rare Pediatric Tumors (STEP)
Flaadt T, Wild H, Abele M, Fruhwald M, Dirksen U, Classen C, et al.
Pediatr Blood Cancer . 2023 Dec; 71(3):e30821. PMID: 38148490
Background And Aims: Nuclear protein of the testis (NUT) carcinoma (NC) is a rare and highly aggressive tumor defined by the presence of a somatic NUTM1 rearrangement, occurring mainly in...
6.
Proton Beam Therapy for Pediatric Tumors of the Central Nervous System-Experiences of Clinical Outcome and Feasibility from the KiProReg Study
Peters S, Frisch S, Stock A, Merta J, Baumer C, Blase C, et al.
Cancers (Basel) . 2022 Dec; 14(23). PMID: 36497345
As radiotherapy is an important part of the treatment in a variety of pediatric tumors of the central nervous system (CNS), proton beam therapy (PBT) plays an evolving role due...
7.
Genotype-phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry
Penkert J, Struwe F, Dutzmann C, Doergeloh B, Montellier E, Freycon C, et al.
J Hematol Oncol . 2022 Aug; 15(1):107. PMID: 35974385
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome caused by pathogenic TP53 variants. The condition represents one of the most relevant genetic causes of cancer in children and adults due...
8.
A randomized controlled trial on long-term effectiveness of a psychosocial aftercare program following paediatric chronic pain treatment: Who benefits the most?
Dogan M, Hirschfeld G, Blankenburg M, Fruhwald M, Ahnert R, Braun S, et al.
Eur J Pain . 2022 Jun; 26(8):1746-1758. PMID: 35762280
Background: For paediatric chronic pain patients, intensive interdisciplinary pain treatment (IIPT) is a well-established treatment. The treatment's short-term effectiveness can be improved by an additive psychosocial aftercare (PAC). However, neither...
9.
Infantile myofibromatosis: Excellent prognosis but also rare fatal progressive disease. Treatment results of five Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry
Sparber-Sauer M, Vokuhl C, Seitz G, Sorg B, Tobias M, von Kalle T, et al.
Pediatr Blood Cancer . 2021 Oct; 69(3):e29403. PMID: 34636137
Background: Infantile myofibromatosis (IM) is a rare benign soft tissue tumor and often a self-limiting disease but rarely includes life-threatening complications. Little is known about optimal treatment of primary localized...
10.
Effectiveness of a Psychosocial Aftercare Program for Youth Aged 8 to 17 Years With Severe Chronic Pain: A Randomized Clinical Trial
Dogan M, Hirschfeld G, Blankenburg M, Fruhwald M, Ahnert R, Braun S, et al.
JAMA Netw Open . 2021 Sep; 4(9):e2127024. PMID: 34570203
Importance: Severe chronic pediatric pain causes individual suffering and significantly affects social functioning and psychological well-being. For children with high pain severity, intensive interdisciplinary pain treatment (IIPT) is a well-established...