Michael F Stone
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Explore the profile of Michael F Stone including associated specialties, affiliations and a list of published articles.
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8
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60
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Recent Articles
1.
Nguyen D, Niquet J, Marrero-Rosado B, Schultz C, Stone M, de Araujo Furtado M, et al.
Exp Neurol
. 2024 Dec;
385:115122.
PMID: 39710244
Exposure to organophosphorus nerve agents irreversibly inhibits acetylcholinesterase and may lead to cholinergic crisis and seizures. Although benzodiazepines are the standard of care after nerve agent-induced status epilepticus, when treatment...
2.
Lumley L, Nguyen D, de Araujo Furtado M, Niquet J, Linz E, Schultz C, et al.
J Pharmacol Exp Ther
. 2023 Nov;
388(2):347-357.
PMID: 37977809
Benzodiazepine pharmacoresistance develops when treatment of status epilepticus (SE) is delayed. This response may result from gamma-aminobutyric acid A receptors (GABAR) internalization that follows prolonged SE; this receptor trafficking results...
3.
Nguyen D, Stone M, Schultz C, de Araujo Furtado M, Niquet J, Wasterlain C, et al.
J Pharmacol Exp Ther
. 2023 Sep;
388(2):376-385.
PMID: 37770198
Status epilepticus (SE) is a life-threatening development of self-sustaining seizures that becomes resistant to benzodiazepines when treatment is delayed. Benzodiazepine pharmacoresistance is thought in part to result from internalization of...
4.
Lumley L, Marrero-Rosado B, Rossetti F, Schultz C, Stone M, Niquet J, et al.
Epilepsia Open
. 2021 Oct;
6(4):757-769.
PMID: 34657398
Objective: Cholinergic-induced status epilepticus (SE) is associated with a loss of synaptic gamma-aminobutyric acid A receptors (GABA R) and an increase in N-methyl-D-aspartate receptors (NMDAR) and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR)...
5.
Marrero-Rosado B, Stone M, de Araujo Furtado M, Schultz C, Cadieux C, Lumley L
Int J Mol Sci
. 2021 Mar;
22(4).
PMID: 33672922
The identification of improved medical countermeasures against exposure to chemical warfare nerve agents (CWNAs), a class of organophosphorus compounds, is dependent on the choice of animal model used in preclinical...
6.
Marrero-Rosado B, de Araujo Furtado M, Kundrick E, Walker K, Stone M, Schultz C, et al.
Epilepsy Behav
. 2020 Jun;
111:107229.
PMID: 32575012
Delayed treatment of cholinergic seizure results in benzodiazepine-refractory status epilepticus (SE) that is thought, at least in part, to result from maladaptive trafficking of N-methyl-d-aspartate (NMDA) and gamma-aminobutyric acid type...
7.
Marrero-Rosado B, Rossetti F, Rice M, Moffett M, Lee R, Stone M, et al.
Toxicol Sci
. 2018 Mar;
164(1):142-152.
PMID: 29596688
Elderly individuals compose a large percentage of the world population; however, few studies have addressed the efficacy of current medical countermeasures (MCMs) against the effects of chemical warfare nerve agent...
8.
Moffett M, Schultz M, Schwartz J, Stone M, Lumley L
Pharmacol Biochem Behav
. 2010 Dec;
98(1):120-9.
PMID: 21144858
Exposure to soman (GD) can result in prolonged seizures and subsequent neuropathology in a variety of brain regions including the amygdala and hippocampus. Both regions are believed to play important...