Michael D Keller
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Explore the profile of Michael D Keller including associated specialties, affiliations and a list of published articles.
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2407
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Recent Articles
11.
Xie V, File W, Wiedl C, Ward B, Davila Saldana B, Keller M, et al.
Allergy Asthma Clin Immunol
. 2023 Aug;
19(1):68.
PMID: 37550789
Background: Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency caused by mutations in the WAS gene that leads to increased susceptibility to infections, thrombocytopenia, eczema, malignancies, and autoimmunity. Central nervous...
12.
Thakar M, Logan B, Puck J, Dunn E, Buckley R, Cowan M, et al.
Lancet
. 2023 Jun;
402(10396):129-140.
PMID: 37352885
Background: Severe combined immunodeficiency (SCID) is fatal unless durable adaptive immunity is established, most commonly through allogeneic haematopoietic cell transplantation (HCT). The Primary Immune Deficiency Treatment Consortium (PIDTC) explored factors...
13.
Beers B, Similuk M, Ghosh R, Seifert B, Jamal L, Kamen M, et al.
Front Immunol
. 2023 May;
14:1172004.
PMID: 37215141
Purpose: Though copy number variants (CNVs) have been suggested to play a significant role in inborn errors of immunity (IEI), the precise nature of this role remains largely unexplored. We...
14.
Motta C, Keller M, Bollard C
Semin Hematol
. 2023 Apr;
60(1):10-19.
PMID: 37080705
Hematopoietic stem cell transplantation (HSCT) has been used as a curative standard of care for moderate to severe primary immunodeficiency disorders as well as relapsed hematologic malignancies for over 50...
15.
Murguia-Favela L, Suresh S, Wright N, Alvi S, Tehseen S, Hernandez-Trujillo V, et al.
J Allergy Clin Immunol Pract
. 2023 Feb;
11(6):1725-1733.
PMID: 36736953
Background: ADAGEN, a bovine-based enzyme replacement therapy (ERT), has been used to treat adenosine deaminase severe combined immunodeficiency (ADA-SCID). In 2018, ADAGEN was replaced by REVCOVI (elapegademase), a modified bovine...
16.
Galletta T, Lane A, Lutzko C, Leemhuis T, Cancelas J, Khoury R, et al.
Transplant Cell Ther
. 2023 Feb;
29(5):305-310.
PMID: 36736781
Infections with double-stranded DNA viruses are a common complication after hematopoietic stem cell transplantation (HSCT) and cause significant morbidity and mortality in the post-transplantation period. Both donor-derived (DD) and third-party...
17.
Outcomes following posttransplant virus-specific T-cell therapy in patients with sickle cell disease
Kinoshita H, Mandava M, Jensen-Wachspress M, Lang H, Joy E, Tanna J, et al.
Blood Adv
. 2022 Dec;
7(10):2105-2116.
PMID: 36516084
Hematopoietic stem cell transplantation (HSCT) is being increasingly used as a curative approach for sickle cell disease (SCD). With the risk of graft-versus-host disease (GVHD), especially in the human leukocyte...
18.
Sacco K, Kuehn H, Kawai T, Alsaati N, Smith L, Davila B, et al.
J Clin Immunol
. 2022 Nov;
43(2):512-520.
PMID: 36378426
Purpose: Biallelic loss-of-function variants in IKBKB cause severe combined immunodeficiency. We describe a case of autoimmunity and autoinflammation in a male infant with a heterozygous gain-of-function (GOF) IKBKB variant. Methods:...
19.
Kubala S, Sandhu A, Palacios-Kibler T, Ward B, Harmon G, DeFelice M, et al.
Clin Immunol
. 2022 Nov;
245:109182.
PMID: 36368643
Newborn screening (NBS) for severe combined immunodeficiency (SCID) can identify infants with non-SCID T cell lymphopenia (TCL). The purpose of this study was to characterize the natural history and genetic...
20.
Ghosh R, Bosticardo M, Singh S, Similuk M, Delmonte O, Pala F, et al.
J Allergy Clin Immunol
. 2022 Aug;
150(6):1556-1562.
PMID: 35987349
Background: Newborn screening can identify neonatal T-cell lymphopenia through detection of a low number of copies of T-cell receptor excision circles in dried blood spots collected at birth. After a...