Michael D Allen
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Explore the profile of Michael D Allen including associated specialties, affiliations and a list of published articles.
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39
Citations
1556
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Recent Articles
1.
Gibson S, Madzharova E, Tan A, Allen M, Auf dem Keller U, Jones J, et al.
Matrix Biol
. 2023 Jun;
121:74-89.
PMID: 37336268
Proteases have long been associated with cancer progression, due to their ability to facilitate invasion upon matrix remodelling. However, proteases are not simply degraders of the matrix, but also play...
2.
Gibson S, Tomas Bort E, Rodriguez-Fernandez L, Allen M, Gomm J, Goulding I, et al.
NPJ Breast Cancer
. 2023 Mar;
9(1):9.
PMID: 36864079
Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable,...
3.
Gibson S, Roozitalab R, Allen M, Jones J, Carter E, Grose R
Trends Cancer
. 2023 Feb;
9(4):326-338.
PMID: 36739265
Ductal carcinoma in situ (DCIS) is a pre-invasive form of breast cancer where neoplastic luminal cells are confined to the ductal tree. While as many as 70% of DCIS cases...
4.
Hayward M, Allen M, Gomm J, Goulding I, Thompson C, Knight M, et al.
NPJ Breast Cancer
. 2022 Sep;
8(1):109.
PMID: 36127361
Women with ductal carcinoma in situ (DCIS) have an increased risk of progression to invasive breast cancer. Although not all women with DCIS will progress to invasion, all are treated...
5.
Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
Saunderson E, Stepper P, Gomm J, Hoa L, Morgan A, Allen M, et al.
Nat Commun
. 2017 Nov;
8(1):1450.
PMID: 29133799
Aberrant promoter DNA hypermethylation is a hallmark of cancer; however, whether this is sufficient to drive cellular transformation is not clear. To investigate this question, we use a CRISPR-dCas9 epigenetic...
6.
Sarper M, Allen M, Gomm J, Haywood L, Decock J, Thirkettle S, et al.
Breast Cancer Res
. 2017 Mar;
19(1):33.
PMID: 28330493
Background: Normal myoepithelial cells (MECs) play an important tumour-suppressor role in the breast but display an altered phenotype in ductal carcinoma in situ (DCIS), gaining tumour-promoter functions. Matrix metalloproteinase-8 (MMP-8)...
7.
Allen M, Jones L
Int J Oncol
. 2015 Jul;
47(3):797-805.
PMID: 26165857
There is a growing interest in the role of the microenvironment in cancer, however, it has been known for over one hundred years that the immune system plays a prominent...
8.
Allen M, Marshall J, Jones J
Cancer Res
. 2014 Oct;
74(21):5942-7.
PMID: 25320004
The tumor microenvironment dynamically regulates the progression of cancer. In the breast, a unique component of the microenvironment is the myoepithelial cell. Normal myoepithelial cells act as "natural tumor suppressors";...
9.
Elosegui-Artola A, Bazellieres E, Allen M, Andreu I, Oria R, Sunyer R, et al.
Nat Mater
. 2014 May;
13(6):631-7.
PMID: 24793358
Tissue rigidity regulates processes in development, cancer and wound healing. However, how cells detect rigidity, and thereby modulate their behaviour, remains unknown. Here, we show that sensing and adaptation to...
10.
Allen M, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, et al.
Cancer Res
. 2013 Nov;
74(3):896-907.
PMID: 24285724
Targeted therapies have yet to have significant impact on the survival of patients with bladder cancer. In this study, we focused on the urea cycle enzyme argininosuccinate synthetase 1 (ASS1)...