Michael C Turchin
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Explore the profile of Michael C Turchin including associated specialties, affiliations and a list of published articles.
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1712
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Recent Articles
1.
Khan A, Turchin M, Patki A, Srinivasasainagendra V, Shang N, Nadukuru R, et al.
Nat Med
. 2022 Jun;
28(7):1412-1420.
PMID: 35710995
Chronic kidney disease (CKD) is a common complex condition associated with high morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; however, this approach has not been optimized...
2.
Belbin G, Rutledge S, Dodatko T, Cullina S, Turchin M, Kohli S, et al.
Am J Hum Genet
. 2021 Oct;
108(11):2099-2111.
PMID: 34678161
The integration of genomic data into health systems offers opportunities to identify genomic factors underlying the continuum of rare and common disease. We applied a population-scale haplotype association approach based...
3.
Turchin M, Stephens M
PLoS Genet
. 2019 Oct;
15(10):e1008431.
PMID: 31596850
Genome-wide association studies (GWAS) have now been conducted for hundreds of phenotypes of relevance to human health. Many such GWAS involve multiple closely-related phenotypes collected on the same samples. However,...
4.
Sohail M, Maier R, Ganna A, Bloemendal A, Martin A, Turchin M, et al.
Elife
. 2019 Mar;
8.
PMID: 30895926
Editorial Note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is...
5.
Simons Y, Turchin M, Pritchard J, Sella G
Nat Genet
. 2014 Feb;
46(3):220-4.
PMID: 24509481
Human populations have undergone major changes in population size in the past 100,000 years, including recent rapid growth. How these demographic events have affected the burden of deleterious mutations in...
6.
Turchin M, Chiang C, Palmer C, Sankararaman S, Reich D, Hirschhorn J
Nat Genet
. 2012 Aug;
44(9):1015-9.
PMID: 22902787
Strong signatures of positive selection at newly arising genetic variants are well documented in humans(1-8), but this form of selection may not be widespread in recent human evolution(9). Because many...
7.
Turchin M, Hirschhorn J
Bioinformatics
. 2012 Feb;
28(6):886-8.
PMID: 22302573
Meta-analysis across genome-wide association studies is a common approach for discovering genetic associations. However, in some meta-analysis efforts, individual-level data cannot be broadly shared by study investigators due to privacy...
8.
Dauber A, Yu Y, Turchin M, Chiang C, Meng Y, Demerath E, et al.
Am J Hum Genet
. 2011 Nov;
89(6):751-9.
PMID: 22118881
Height is a model polygenic trait that is highly heritable. Genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with stature, but the role of structural variation in determining...
9.
Lango Allen H, Estrada K, Lettre G, Berndt S, Weedon M, Rivadeneira F, et al.
Nature
. 2010 Oct;
467(7317):832-8.
PMID: 20881960
Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than...
10.
Wong A, Turchin M, Wolfner M, Aquadro C
Mol Biol Evol
. 2007 Dec;
25(3):497-506.
PMID: 18056920
Proteins present in the seminal fluid of Drosophila melanogaster (accessory gland proteins Acps) contribute to female postmating behavioral changes, sperm storage, sperm competition, and immunity. Consequently, male-female coevolution and host-pathogen...