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Michael Buttner

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Articles 44
Citations 908
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Recent Articles
1.
Broker-Lai J, Rego Terol J, Richter C, Mathar I, Wirth A, Kopf S, et al.
EMBO J . 2024 Oct; 43(23):5813-5836. PMID: 39375537
Hypoglycemia triggers autonomic and endocrine counter-regulatory responses to restore glucose homeostasis, a response that is impaired in patients with diabetes and its long-term complication hypoglycemia-associated autonomic failure (HAAF). We show...
2.
Madai S, Kilic P, Schmidt R, Bas-Orth C, Korff T, Buttner M, et al.
Theranostics . 2024 May; 14(7):2856-2880. PMID: 38773968
Cell metabolism reprogramming to sustain energy production, while reducing oxygen and energy consuming processes is crucially important for the adaptation to hypoxia/ischemia. Adaptive metabolic rewiring is controlled by hypoxia-inducible factors...
3.
Mandel N, Buttner M, Poschet G, Kuner R, Agarwal N
Cells . 2023 Nov; 12(21). PMID: 37947589
Diabetic peripheral neuropathy (DPN) is the prevalent type of peripheral neuropathy; it primarily impacts extremity nerves. Its multifaceted nature makes the molecular mechanisms of diabetic neuropathy intricate and incompletely elucidated....
4.
Urschel K, Hug K, Zuo H, Buttner M, Furtmair R, Kuehn C, et al.
Int J Mol Sci . 2023 Jul; 24(14). PMID: 37511353
Retention of circulating lipoproteins by their interaction with extracellular matrix molecules has been suggested as an underlying mechanism for atherosclerosis. We investigated the role of glypican-4 (GPC4), a heparan sulfate...
5.
Yaz F, Buttner M, Tekin A, Bahsi I, Topsakal V
J Int Adv Otol . 2023 Jan; 19(2):121-129. PMID: 36648030
Background: The incidence of tinnitus has been increasing together with its patient impact and societal costs. Much research has been conducted in the field of tinnitus, especially on treatment modalities...
6.
Michalaki A, McGivern A, Poschet G, Buttner M, Altenburger R, Grintzalis K
Toxics . 2022 Oct; 10(10). PMID: 36287884
The continuous global increase in population and consumption of resources due to human activities has had a significant impact on the environment. Therefore, assessment of environmental exposure to toxic chemicals...
7.
Alborzinia H, Florez A, Kreth S, Bruckner L, Yildiz U, Gartlgruber M, et al.
Nat Cancer . 2022 Apr; 3(4):471-485. PMID: 35484422
Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance....
8.
Laban H, Siegmund S, Zappe M, Trogisch F, Heineke J, de la Torre C, et al.
Cells . 2021 Dec; 10(12). PMID: 34943801
Chronic hypoxia increases the resistance of pulmonary arteries by stimulating their contraction and augmenting their coverage by smooth muscle cells (SMCs). While these responses require adjustment of the vascular SMC...
9.
Schenz J, Heilig L, Lohse T, Tichy L, Bomans K, Buttner M, et al.
Front Immunol . 2021 Dec; 12:729209. PMID: 34899690
Elevated blood lactate levels are frequently found in critically ill patients and thought to result from tissue hypoperfusion and cellular oxygen shortage. Considering the close relationship between immune cell function...
10.
Pioronska W, Nwosu Z, Han M, Buttner M, Ebert M, Dooley S, et al.
BMC Cancer . 2021 Sep; 21(1):1006. PMID: 34496784
Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death. Paired related homeobox 1 (PRRX1) is a transcription factor that regulates cell growth and differentiation, but its importance in...