Michael B Simmers
Overview
Explore the profile of Michael B Simmers including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
272
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0
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Recent Articles
1.
Roller D, Hoang S, Rawls K, Owen K, Simmers M, Figler R, et al.
Sci Rep
. 2021 Mar;
11(1):5535.
PMID: 33692370
Lung cancer rates are rising globally and non-small cell lung cancer (NSCLC) has a five year survival rate of only 24%. Unfortunately, the development of drugs to treat cancer is...
2.
Gioeli D, Snow C, Simmers M, Hoang S, Figler R, Allende J, et al.
Lab Chip
. 2019 Mar;
19(7):1193-1204.
PMID: 30839006
The development of drugs to treat cancer is hampered by the inefficiency of translating pre-clinical in vitro monoculture and mouse studies into clinical benefit. There is a critical need to...
3.
Collado M, Cole B, Figler R, Lawson M, Manka D, Simmers M, et al.
Stem Cells Transl Med
. 2017 Jun;
6(8):1673-1683.
PMID: 28628273
Human induced pluripotent stem cells (iPSCs) can be differentiated into vascular endothelial (iEC) and smooth muscle (iSMC) cells. However, because iECs and iSMCs are not derived from an intact blood...
4.
Simmers M, Cole B, Ogletree M, Chen Z, Xu Y, Kong L, et al.
Thromb Res
. 2016 May;
143:34-9.
PMID: 27179130
An experimental in vitro model of the hemodynamics that occur in atrial fibrillation (AFib) in the left atrial appendage (LAA) was developed to study changes in human endothelial cell thrombotic...
5.
Chapman K, Collado M, Figler R, Hoang S, Armstrong A, Cui W, et al.
Mol Genet Metab
. 2016 Jan;
117(3):355-362.
PMID: 26740382
Background: Propionic acidemia (PA) is a disorder of intermediary metabolism with defects in the alpha or beta subunits of propionyl CoA carboxylase (PCCA and PCCB respectively) enzyme. We previously described...
6.
Cole B, Simmers M, Feaver R, Qualls Jr C, Collado M, Berzin E, et al.
Arterioscler Thromb Vasc Biol
. 2015 Aug;
35(10):2185-95.
PMID: 26293464
Objectives: The predictive value of animal and in vitro systems for drug development is limited, particularly for nonhuman primate studies as it is difficult to deduce the drug mechanism of...
7.
Hastings N, Simmers M, McDonald O, Wamhoff B, Blackman B
Am J Physiol Cell Physiol
. 2007 Oct;
293(6):C1824-33.
PMID: 17913848
Atherosclerosis is an inflammatory disease that preferentially forms at hemodynamically compromised regions of altered shear stress patterns. Endothelial cells (EC) and smooth muscle cells (SMC) undergo phenotypic modulation during atherosclerosis....
8.
Simmers M, Pryor A, Blackman B
Am J Physiol Heart Circ Physiol
. 2007 Jun;
293(3):H1937-46.
PMID: 17586613
Hemodynamic regulation of directional endothelial cell (EC) migration implies an essential role of shear stress in governing EC polarity. Shear stress induces reorientation of the microtubule organizing center toward the...
9.
Orr A, Stockton R, Simmers M, Sanders J, Sarembock I, Blackman B, et al.
J Cell Biol
. 2007 Feb;
176(5):719-27.
PMID: 17312022
Elevated permeability of the endothelium is thought to be crucial in atherogenesis because it allows circulating lipoproteins to access subendothelial monocytes. Both local hemodynamics and cytokines may govern endothelial permeability...