Michael Alvarsson
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Explore the profile of Michael Alvarsson including associated specialties, affiliations and a list of published articles.
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38
Citations
553
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Recent Articles
11.
Mahdi A, Tratsiakovich Y, Tengbom J, Jiao T, Garib L, Alvarsson M, et al.
Front Pharmacol
. 2021 Jan;
11:603226.
PMID: 33390992
It is well established that altered purinergic signaling contributes to vascular dysfunction in type 2 diabetes (T2D). Red blood cells (RBCs) serve as an important pool for circulating ATP and...
12.
Knudsen S, Bodegard J, Birkeland K, Furuseth K, Thuresson M, Lindh A, et al.
Prim Care Diabetes
. 2020 Oct;
15(2):262-268.
PMID: 33032936
Aims: To observe and report population demography, comorbidities, risk factor levels and risk factor treatment in a sample of individuals treated for type 2 diabetes in primary care in Norway,...
13.
Secnik J, Xu H, Schwertner E, Hammar N, Alvarsson M, Winblad B, et al.
J Alzheimers Dis
. 2020 Aug;
76(4):1581-1594.
PMID: 32741836
Background: Care individualization dominates in clinical guidelines for cognitively impaired patients with diabetes; however, few studies examined such adaptations. Objective: Describe long-term pharmacological changes in diabetes treatment in subjects with...
14.
Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase
Mahdi A, Tengbom J, Alvarsson M, Wernly B, Zhou Z, Pernow J
Cells
. 2020 Jul;
9(7).
PMID: 32708826
We recently showed that red blood cells (RBCs) from patients with type 2 diabetes mellitus (T2DM-RBCs) induce endothelial dysfunction through a mechanism involving arginase I and reactive oxygen species. Peroxynitrite...
15.
Secnik J, Schwertner E, Alvarsson M, Hammar N, Fastbom J, Winblad B, et al.
BMJ Open Diabetes Res Care
. 2020 Jan;
8(1).
PMID: 31958305
Objective: Cholinesterase inhibitors (ChEIs) and memantine are the only approved pharmacological treatments for Alzheimer's disease (AD). Recent literature suggests reductions in cardiovascular burden and risk of stroke in ChEI users....
16.
Littmann K, Wodaje T, Alvarsson M, Bottai M, Eriksson M, Parini P, et al.
Diabetes Care
. 2019 Dec;
43(8):1851-1858.
PMID: 31862789
Objective: To investigate the association of the cardiovascular risk factor lipoprotein (Lp)(a) and vascular complications in patients with type 1 diabetes. Research Design And Methods: Patients with type 1 diabetes...
17.
Mahdi A, Jiao T, Yang J, Kovamees O, Alvarsson M, von Heijne M, et al.
Front Pharmacol
. 2019 Aug;
10:861.
PMID: 31427970
Red blood cells (RBCs) from patients with type 2 diabetes mellitus (T2DM) induce endothelial dysfunction and impair cardiac function following ischemia increase in RBC arginase and oxidative stress. Here, we...
18.
Bethel M, Engel S, Stevens S, Lokhnygina Y, Ding J, Josse R, et al.
Endocrinol Diabetes Metab
. 2019 Mar;
2(1):e00053.
PMID: 30815579
Aims: TECOS was a randomized, double-blind, placebo-controlled trial assessing the impact of sitagliptin vs. placebo on cardiovascular outcomes when added to usual care in patients with type 2 diabetes. We...
19.
Yang J, Zheng X, Mahdi A, Zhou Z, Tratsiakovich Y, Jiao T, et al.
JACC Basic Transl Sci
. 2018 Sep;
3(4):450-463.
PMID: 30175269
This study tested the hypothesis that red blood cell (RBC) arginase represents a potential therapeutic target in ischemia-reperfusion in type 2 diabetes. Post-ischemic cardiac recovery was impaired in hearts from...
20.
Zhou Z, Mahdi A, Tratsiakovich Y, Zahoran S, Kovamees O, Nordin F, et al.
J Am Coll Cardiol
. 2018 Aug;
72(7):769-780.
PMID: 30092954
Background: Cardiovascular complications are major clinical problems in type 2 diabetes mellitus (T2DM). The authors previously demonstrated a crucial role of red blood cells (RBCs) in control of cardiac function...