Michael A Portelli
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Explore the profile of Michael A Portelli including associated specialties, affiliations and a list of published articles.
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16
Citations
367
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Recent Articles
1.
Portelli M, Ketelaar M, Bates S, Csomor E, Shaw D, Emsley J, et al.
Clin Exp Allergy
. 2024 Sep;
54(12):984-995.
PMID: 39301832
Introduction: The interleukin-33/interleukin-1 receptor-like-1 (IL-33/IL1RL1) signalling pathway is implicated in asthma pathogenesis, with IL1RL1 nonsynonymous genetic polymorphisms associated with disease risk. We aimed to determine these variants' effect on IL1RL1...
2.
Rakkar K, Thakker D, Portelli M, Hall I, Schluter H, Sayers I
ERJ Open Res
. 2024 Aug;
10(4).
PMID: 39104962
https://bit.ly/3JoW73H.
3.
Rakkar K, Pang Y, Rajasekar P, Portelli M, Hall R, Clifford R, et al.
Am J Respir Crit Care Med
. 2024 Feb;
209(10):1268-1272.
PMID: 38386780
No abstract available.
4.
Portelli M, Bhaker S, Pang V, Bates D, Johnson S, Mazar A, et al.
Clin Transl Allergy
. 2023 Oct;
13(10):e12293.
PMID: 37876037
Background: Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting...
5.
Portelli M, Rakkar K, Hu S, Guo Y, Adcock I, Sayers I
Front Allergy
. 2022 Apr;
2:738741.
PMID: 35386986
Asthma affects more than 300 million people globally and is both under diagnosed and under treated. The most recent and largest genome-wide association study investigating moderate to severe asthma to...
6.
Bhaker S, Portelli M, Rakkar K, Shaw D, Johnson S, Brightling C, et al.
ERJ Open Res
. 2022 Feb;
8(1).
PMID: 35198626
https://bit.ly/3Cq2xKf.
7.
OLoughlin J, Hall R, Bhaker S, Portelli M, Henry A, Pang V, et al.
ERJ Open Res
. 2021 Feb;
7(1).
PMID: 33532474
Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently exceed the proliferative potential of primary human bronchial epithelial cells (HBECs)...
8.
Ketelaar M, Portelli M, Dijk F, Shrine N, Faiz A, Vermeulen C, et al.
J Allergy Clin Immunol
. 2020 May;
147(1):144-157.
PMID: 32442646
Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33...
9.
Portelli M, Dijk F, Ketelaar M, Shrine N, Hankinson J, Bhaker S, et al.
JCI Insight
. 2020 Apr;
5(8).
PMID: 32324168
The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying...
10.
Shrine N, Portelli M, John C, Artigas M, Bennett N, Hall R, et al.
Lancet Respir Med
. 2018 Dec;
7(1):20-34.
PMID: 30552067
Background: Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types...