Michael A Laffan
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Explore the profile of Michael A Laffan including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Ahnstrom J, Gierula M, Temenu J, Laffan M, Lane D
J Thromb Haemost
. 2019 Aug;
18(1):136-150.
PMID: 31466141
Background: Activated coagulation factor X (FXa) is the serine protease component of prothrombinase, the physiological activator of prothrombin. Factor X Nottingham (A404T) and Taunton (R405G) are two naturally occurring mutations,...
12.
Lentaigne C, Greene D, Sivapalaratnam S, Favier R, Seyres D, Thys C, et al.
Blood
. 2019 Jun;
134(23):2070-2081.
PMID: 31217188
To identify novel causes of hereditary thrombocytopenia, we performed a genetic association analysis of whole-genome sequencing data from 13 037 individuals enrolled in the National Institute for Health Research (NIHR)...
13.
Downes K, Megy K, Duarte D, Vries M, Gebhart J, Hofer S, et al.
Blood
. 2019 May;
134(23):2082-2091.
PMID: 31064749
A targeted high-throughput sequencing (HTS) panel test for clinical diagnostics requires careful consideration of the inclusion of appropriate diagnostic-grade genes, the ability to detect multiple types of genomic variation with...
14.
Westbury S, Downes K, Burney C, Lozano M, Obaji S, Toh C, et al.
Blood Adv
. 2018 Sep;
2(18):2341-2346.
PMID: 30232087
No abstract available.
15.
Gill D, Del Greco M F, Walker A, Srai S, Laffan M, Minelli C
Arterioscler Thromb Vasc Biol
. 2017 Jul;
37(9):1788-1792.
PMID: 28684612
Objective: Iron status is a modifiable trait that has been implicated in cardiovascular disease. This study uses the Mendelian randomization technique to investigate whether there is any causal effect of...
16.
Westbury S, Canault M, Greene D, Bermejo E, Hanlon K, Lambert M, et al.
Blood
. 2017 Jun;
130(8):1026-1030.
PMID: 28637664
Heritable platelet function disorders (PFDs) are genetically heterogeneous and poorly characterized. Pathogenic variants in , which encodes calcium and diacylglycerol-regulated guanine exchange factor I (CalDAG-GEFI), have been reported previously in...
17.
Sivapalaratnam S, Westbury S, Stephens J, Greene D, Downes K, Kelly A, et al.
Blood
. 2017 Jan;
129(4):520-524.
PMID: 28064200
The von Willebrand receptor complex, which is composed of the glycoproteins Ibα, Ibβ, GPV, and GPIX, plays an essential role in the earliest steps in hemostasis. During the last 4...
18.
Chamali B, Finnamore H, Manning R, Laffan M, Hickson M, Whelan K, et al.
Intractable Rare Dis Res
. 2016 May;
5(2):109-13.
PMID: 27195194
Understanding potential provocations of haemorrhage is important in a range of clinical settings, and particularly for people with abnormal vasculature. Patients with hereditary haemorrhagic telangiectasia (HHT) can report haemorrhage from...
19.
Lentaigne C, Freson K, Laffan M, Turro E, Ouwehand W
Blood
. 2016 Apr;
127(23):2814-23.
PMID: 27095789
Variations in platelet number, volume, and function are largely genetically controlled, and many loci associated with platelet traits have been identified by genome-wide association studies (GWASs).(1) The genome also contains...
20.
Simeoni I, Stephens J, Hu F, Deevi S, Megy K, Bariana T, et al.
Blood
. 2016 Apr;
127(23):2791-803.
PMID: 27084890
Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect ∼300 individuals per million births. With the exception of hemophilia and von Willebrand disease patients, a molecular analysis for...