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Michael A Helmrath

Explore the profile of Michael A Helmrath including associated specialties, affiliations and a list of published articles. Areas
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Articles 117
Citations 3740
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Recent Articles
1.
Childs C, Poling H, Chen K, Tsai Y, Wu A, Vallie A, et al.
Cell Stem Cell . 2025 Mar; PMID: 40043706
Human intestinal organoids (HIOs) derived from human pluripotent stem cells co-differentiate both epithelial and mesenchymal lineages in vitro but lack important cell types such as neurons, endothelial cells, and smooth...
2.
Tominaga K, Kechele D, Sanchez J, Vales S, Jurickova I, Roman L, et al.
Cell Mol Gastroenterol Hepatol . 2024 Dec; 19(4):101444. PMID: 39701210
Background & Aims: Organs of the gastrointestinal tract contain tissue-resident immune cells that function during tissue development, homeostasis, and disease. However, most published human organoid model systems lack resident immune...
3.
Ryder J, Jenkins T, Xie C, Courcoulas A, Harmon C, Helmrath M, et al.
N Engl J Med . 2024 Oct; 391(17):1656-1658. PMID: 39476348
No abstract available.
4.
Shi M, Crouse B, Sundaram N, Pode Shakked N, Ester L, Zhang W, et al.
bioRxiv . 2024 Sep; PMID: 39345524
The kidney maintains homeostasis through an array of parallel nephrons, which all originate in development as isolated epithelial structures that later fuse through their distal poles to a system of...
5.
Poling H, Sundaram N, Fisher G, Singh A, Shiley J, Nattamai K, et al.
Cell Stem Cell . 2024 Sep; 31(10):1513-1523.e7. PMID: 39270642
The fundamental goal of tissue engineering is to functionally restore or improve damaged tissues or organs. Here we address this in the small bowel using an in vivo xenograft preclinical...
6.
Krutko M, Poling H, Bryan A, Sharma M, Singh A, Reza H, et al.
bioRxiv . 2024 Sep; PMID: 39229142
This study investigates bioelectric stimulation's role in tissue regeneration by enhancing the piezoelectric properties of tissue-engineered grafts using annealed poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE) scaffolds. Annealing at temperatures of 80°C, 100°C, 120°C,...
7.
Jurickova I, Dreskin B, Angerman E, Bonkowski E, Nguyen J, Villarreal R, et al.
J Crohns Colitis . 2024 Aug; 19(2). PMID: 39212594
Background And Aims: We previously identified small molecules predicted to reverse an ileal gene signature for future Crohn's Disease (CD) strictures. Here we used a new human intestinal organoid (HIO)...
8.
Poling H, Brown N, Wells J, Barrile R, Helmrath M, Mahe M
Biophys Rev (Melville) . 2024 Jul; 5(3):032102. PMID: 39036707
No abstract available.
9.
Poling H, Singh A, Krutko M, Reza A, Srivastava K, Wells J, et al.
bioRxiv . 2024 Jun; PMID: 38915647
Human organoid model systems have changed the landscape of developmental biology and basic science. They serve as a great tool for human specific interrogation. In order to advance our organoid...
10.
Miao Y, Tan C, Pek N, Yu Z, Iwasawa K, Kechele D, et al.
bioRxiv . 2024 Feb; PMID: 38370768
Highlights: BMP signaling fine-tunes the co-differentiation of mesoderm and endoderm.The cellular composition in multilineage organoids resembles that of human fetal organs.Mesenchyme and endothelium co-developed within the organoids adopt organ-specific characteristics.Multilineage...