Metin Aksu
Overview
Explore the profile of Metin Aksu including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
139
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0
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Recent Articles
1.
Aksu M, Kaschke K, Podojil J, Chiang M, Steckler I, Bruce K, et al.
Glia
. 2025 Feb;
PMID: 39928347
Inflammation-induced oligodendrocyte death and CNS demyelination are key features of multiple sclerosis (MS). Inflammation-triggered endoplasmic reticulum (ER) stress and oxidative stress promote tissue damage in MS and in its preclinical...
2.
Aksu M, Kumar P, Guttler T, Taxer W, Gregor K, Mussil B, et al.
Antiviral Res
. 2023 Dec;
221:105778.
PMID: 38065245
The ongoing threat of COVID-19 has highlighted the need for effective prophylaxis and convenient therapies, especially for outpatient settings. We have previously developed highly potent single-domain (VHH) antibodies, also known...
3.
Akkermans O, Delloye-Bourgeois C, Peregrina C, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, et al.
Cell
. 2022 Oct;
185(21):3931-3949.e26.
PMID: 36240740
Neural migration is a critical step during brain development that requires the interactions of cell-surface guidance receptors. Cancer cells often hijack these mechanisms to disseminate. Here, we reveal crystal structures...
4.
Guttler T, Aksu M, Dickmanns A, Stegmann K, Gregor K, Rees R, et al.
EMBO J
. 2021 Jul;
40(19):e107985.
PMID: 34302370
Monoclonal anti-SARS-CoV-2 immunoglobulins represent a treatment option for COVID-19. However, their production in mammalian cells is not scalable to meet the global demand. Single-domain (VHH) antibodies (also called nanobodies) provide...
5.
Aksu M, Trakhanov S, Vera Rodriguez A, Gorlich D
J Cell Biol
. 2019 Apr;
218(6):1839-1852.
PMID: 31023722
Importins ferry proteins into nuclei while exportins carry cargoes to the cytoplasm. In the accompanying paper in this issue (Vera Rodriguez et al. 2019. https://doi.org/10.1083/jcb.201812091), we discovered that Pdr6 is...
6.
Aksu M, Seiradake E
Neuron
. 2018 Dec;
100(6):1270-1272.
PMID: 30571936
The nervous system relies on a combinatorial code of protein interactions that determine wiring specificity. Two complementary studies by Cosmanescu et al. (2018) and Xu et al. (2018) present the...
7.
Aksu M, Pleiner T, Karaca S, Kappert C, Dehne H, Seibel K, et al.
J Cell Biol
. 2018 May;
217(7):2329-2340.
PMID: 29748336
Exportins bind cargo molecules in a RanGTP-dependent manner inside nuclei and transport them through nuclear pores to the cytoplasm. CRM1/Xpo1 is the best-characterized exportin because specific inhibitors such as leptomycin...
8.
Aksu M, Trakhanov S, Gorlich D
Nat Commun
. 2016 Jun;
7:11952.
PMID: 27306458
Xpo4 is a bidirectional nuclear transport receptor that mediates nuclear export of eIF5A and Smad3 as well as import of Sox2 and SRY. How Xpo4 recognizes such a variety of...