Mercedes Segovia
Overview
Explore the profile of Mercedes Segovia including associated specialties, affiliations and a list of published articles.
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14
Citations
231
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Recent Articles
1.
Victoria S, Castro A, Pittini A, Olivera D, Russo S, Cebrian I, et al.
Int J Biol Macromol
. 2024 Sep;
279(Pt 3):135327.
PMID: 39236955
The immunoregulatory cation channel TMEM176B plays a dual role in tumor immunity. On the one hand, TMEM176B promotes antigen cross-presentation to CD8 T cells by regulating phagosomal pH in dendritic...
2.
Castellano M, Blanco V, Calzi M, Costa B, Witwer K, Hill M, et al.
bioRxiv
. 2024 May;
PMID: 38712104
The plasma membrane and the membrane of endosomal vesicles are considered physical barriers preventing extracellular RNA uptake. While naked RNA can be spontaneously internalized by certain cells types, functional delivery...
3.
Miranda P, Castro A, Rodriguez Grassi L, Davyt D, Hill M, Segovia M, et al.
J Chromatogr Sci
. 2024 Mar;
62(9):829-836.
PMID: 38553777
Following ICH guidelines for analytical validation, we report a common C18 column stability indicating isocratic reverse phase high performance liquid chromatography method for the determination of the ion channel modulator...
4.
Hill M, Russo S, Olivera D, Malcuori M, Galliussi G, Segovia M
Front Cell Dev Biol
. 2022 Nov;
10:1038429.
PMID: 36340035
Characterizing immune regulatory pathways is critical to understand physiological and pathophysiological processes as well as to identify novel immunotherapeutic targets. The cation channel TMEM176B has emerged in the last years...
5.
Duhalde Vega M, Olivera D, Davanzo G, Bertullo M, Noya V, Fabiano de Souza G, et al.
Sci Adv
. 2022 Sep;
8(38):eabn6545.
PMID: 36129987
Severe COVID-19 is associated with hyperinflammation and weak T cell responses against SARS-CoV-2. However, the links between those processes remain partially characterized. Moreover, whether and how therapeutically manipulating T cells...
6.
Hill M, Segovia M, Russo S, Girotti M, Rabinovich G
Trends Immunol
. 2020 Oct;
41(11):982-993.
PMID: 33036910
Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here, we elaborate on this controversy and propose a new perspective that...
7.
Tosar J, Segovia M, Castellano M, Gambaro F, Akiyama Y, Fagundez P, et al.
Nucleic Acids Res
. 2020 Aug;
48(22):12874-12888.
PMID: 32785615
A major proportion of extracellular RNAs (exRNAs) do not copurify with extracellular vesicles (EVs) and remain in ultracentrifugation supernatants of cell-conditioned medium or mammalian blood serum. However, little is known...
8.
Segovia M, Russo S, Jeldres M, Mahmoud Y, Perez V, Duhalde M, et al.
Cancer Cell
. 2019 May;
35(5):767-781.e6.
PMID: 31085177
Although immune checkpoint blockers have yielded significant clinical benefits in patients with different malignancies, the efficacy of these therapies is still limited. Here, we show that disruption of transmembrane protein...
9.
Carretero-Iglesia L, Bouchet-Delbos L, Louvet C, Drujont L, Segovia M, Merieau E, et al.
Transplantation
. 2016 Sep;
100(10):2079-2089.
PMID: 27653226
Background: Regulatory myeloid cell (RMC) therapy is a promising strategy for the treatment of immunological disorders such as autoimmune disease and allograft transplant rejection. Various RMC subsets can be derived...
10.
Moreau A, Vandamme C, Segovia M, Devaux M, Guilbaud M, Tilly G, et al.
Mol Ther Methods Clin Dev
. 2015 May;
1:14028.
PMID: 26015970
Preventing untoward immune responses against a specific antigen is a major challenge in different clinical settings such as gene therapy, transplantation, or autoimmunity. Following intramuscular delivery of recombinant adeno-associated virus...