Meng Shyan Choy
Overview
Explore the profile of Meng Shyan Choy including associated specialties, affiliations and a list of published articles.
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8
Citations
120
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Recent Articles
1.
Yap Y, Chen M, Choy M, Peng Z, Whiteman M, Manikandan J, et al.
Life Sci
. 2010 Sep;
87(15-16):457-67.
PMID: 20837029
Aims: With the identification of hypochlorous acid (HOCl) as a biomarker in diseased brains and endogenous detection of its modified proteins, HOCl might be implicated in the development of neurodegenerative...
2.
Choy M, Chen M, Manikandan J, Peng Z, Jenner A, Melendez A, et al.
J Cell Physiol
. 2010 Aug;
226(2):494-510.
PMID: 20683911
Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. We and others demonstrated that treatment of...
3.
Chen M, Sepramaniam S, Armugam A, Choy M, Manikandan J, Melendez A, et al.
Curr Neuropharmacol
. 2009 Mar;
6(2):102-16.
PMID: 19305791
Programmed cell death (PCD), is a highly regulated and sophisticated cellular mechanism that commits cell to isolated death fate. PCD has been implicated in the pathogenesis of numerous neurodegenerative disorders....
4.
Peng Z, Chen M, Yap Y, Manikandan J, Melendez A, Choy M, et al.
Nitric Oxide
. 2007 Dec;
18(2):136-45.
PMID: 18078831
Nitric oxide (NO), ubiquitously expressed in the central nervous system, has been perceived to be a potential neuromodulator. Employing cultured murine primary cortical neurons, NO resulted in an inhibition of...
5.
Choy M, Bay B, Cheng H, Cheung N
Neurosci Lett
. 2006 Jul;
405(1-2):120-5.
PMID: 16857313
The tumor suppressor PTEN (phosphatase and tensin homolog deleted from chromosome 10) is a novel phosphatase displaying both protein and lipid phosphatase activities. In the central nervous system, PTEN plays...
6.
Chen M, Yap Y, Choy M, Koh C, Seet S, Duan W, et al.
Neurosci Lett
. 2006 Jan;
397(1-2):69-73.
PMID: 16412576
Rotenone is an inhibitor of mitochondrial complex I that produces a model of Parkinson's disease (PD), where neurons undergo apoptosis by caspase-dependent and/or caspase-independent pathways. Inhibition of calpains has recently...
7.
Yew E, Cheung N, Choy M, Qi R, Lee A, Peng Z, et al.
J Neurochem
. 2005 Jul;
94(4):943-56.
PMID: 15992382
Although inhibition of the ubiquitin proteasome system has been postulated to play a key role in the pathogenesis of neurodegenerative diseases, studies have also shown that proteasome inhibition can induce...
8.
Cheung N, Koh C, Bay B, Qi R, Choy M, Li Q, et al.
Biochem Biophys Res Commun
. 2004 Feb;
315(2):408-17.
PMID: 14766223
Niemann-Pick disease type C (NPC) is a juvenile neurodegenerative disorder characterized by premature neuronal loss and altered cholesterol metabolism. Previous reports applying an 8-h exposure of U18666A, a cholesterol transport-inhibiting...