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Meng Michelle Xu

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Articles 14
Citations 1803
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Recent Articles
1.
Wang Y, Zhang S, Kang N, Dong L, Ni H, Liu S, et al.
Immunity . 2024 Oct; 57(11):2547-2564.e12. PMID: 39476842
Antigen-specific antibodies are generated by antibody-secreting cells (ASCs). How RNA post-transcriptional modification affects antibody homeostasis remains unclear. Here, we found that mRNA polyadenylations and N6-methyladenosine (m6A) modifications maintain IgG1 antibody...
2.
You M, Liu J, Li J, Ji C, Ni H, Guo W, et al.
Cell Rep . 2023 Jun; 42(6):112584. PMID: 37267102
N-methyladenosine (mA) methyltransferase Mettl3 is involved in conventional T cell immunity; however, its role in innate immune cells remains largely unknown. Here, we show that Mettl3 intrinsically regulates invariant natural...
3.
Han D, Xu M
Annu Rev Immunol . 2023 May; 41:73-98. PMID: 37126422
Characterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of...
4.
Akkari L, Finley S, Ho P, Jenkins M, Maier B, McGranahan N, et al.
Nat Cancer . 2022 Feb; 2(12):1278-1283. PMID: 35121916
No abstract available.
5.
Zhang X, Cong T, Wei L, Zhong B, Wang X, Sun J, et al.
Haematologica . 2022 Feb; 107(10):2381-2394. PMID: 35112553
Hematopoietic stem cells (HSC) give rise to the cells of the blood system over the whole lifespan. N6-methyladenosine (m6A), the most prevalent RNA modification, modulates gene expression via the processes...
6.
Dong L, Chen C, Zhang Y, Guo P, Wang Z, Li J, et al.
Cancer Cell . 2021 May; 39(7):945-957.e10. PMID: 34019807
Tumor-associated macrophages (TAMs) can dampen the antitumor activity of T cells, yet the underlying mechanism remains incompletely understood. Here, we show that C1q TAMs are regulated by an RNA N-methyladenosine...
7.
Liu Y, Liang G, Xu H, Dong W, Dong Z, Qiu Z, et al.
Cell Metab . 2021 Apr; 33(6):1221-1233.e11. PMID: 33910046
The ever-increasing understanding of the complexity of factors and regulatory layers that contribute to immune evasion facilitates the development of immunotherapies. However, the diversity of malignant tumors limits many known...
8.
Liu J, Dou X, Chen C, Chen C, Liu C, Xu M, et al.
Science . 2020 Jan; 367(6477):580-586. PMID: 31949099
-methyladenosine (mA) regulates stability and translation of messenger RNA (mRNA) in various biological processes. In this work, we show that knockout of the mA writer or the nuclear reader in...
9.
Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, et al.
Nature . 2019 Mar; 568(7751):E3. PMID: 30911170
In this Letter, a citation to 'Fig. 1e' has been corrected to 'Fig. 1d' in the sentence starting "By contrast, the anti-tumour response…". This has been corrected online.
10.
Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, et al.
Nature . 2019 Feb; 566(7743):270-274. PMID: 30728504
There is growing evidence that tumour neoantigens have important roles in generating spontaneous antitumour immune responses and predicting clinical responses to immunotherapies. Despite the presence of numerous neoantigens in patients,...